Substance abuse and dependence testing is an important aspect of the development of antipsychotic medications and can provide critical safety information. Ace Therapeutics employs rodent models to assist clients in a comprehensive assessment of the abuse potential of prospective antipsychotic candidates. We provide the appropriate animal models and behavioral testing to help our clients identify potential risks of drug abuse and dependence, thereby accelerating their antipsychotic drug development programs.

How We Can Help You Conduct Antipsychotic Abuse and Dependence Testing

• Animal model selection

We provide a range of commonly used animal models to assist our clients with drug abuse and dependence testing, including mice and rats. Our experienced team will select the most suitable animal model for your specific requirements.

• Drug abuse and dependence testing

Ace Therapeutics utilizes comprehensive behavioral tests to help clients identify potential risks of substance abuse and dependence. These behavioral tests include:

• Self-administration test of antipsychotics
• Self-administration test of antipsychotics
• Conditioned place preference or aversion tests of antipsychotics
• Relapse and withdrawal behavior tests

• Physiological indicators monitoring

Our advanced instrumentation and platform technology enable us to conduct comprehensive monitoring of various physiological indicators in animals after drug administration. This allows us to ensure adequate assessment of the risk of abuse and dependence of drug candidates. The most commonly used physiological parameters include neurotransmitter levels, EEG activity, brain imaging, and drug concentrations in the blood.

How Can Abuse and Dependence Testing Accelerate Your Antipsychotic Drugs Development Plan?

• Identify potential safety risks: Test results facilitate the identification of potential safety risks in advance, thereby ensuring the safety of the drug.
• Fulfillment of regulatory requirements: Provide regulators with detailed data related to drug abuse and dependence testing during the drug registration process.
• Insights on pharmacological mechanisms: Explore the neurobiological basis of drug action, particularly the role of neurotransmitters and receptors associated with the reward system.
• Facilitation of drug design and optimization: Assist pharmaceutical developers in the selection of compounds with a lower risk of abuse and dependence for further development and optimization. This will enable the design of safer drug candidates.

Our Service Process

• Requirements analysis: Communicate with the client to understand the drug's characteristics, R&D objectives and regulatory requirements.
• Program design: Design a detailed abuse and dependence testing program based on drug properties and customer requirements.
• Experiment execution: Strictly execute the tests according to the protocol to ensure the standardization and normalization of the experiments.
• Data analysis: Collect experimental data efficiently and analyze them with professional software.
• Report preparation: Write a detailed test report, including experimental methodology, interpretation of results and safety evaluation.
• Feedback: Discuss the test results with the client and provide follow-up R&D suggestions and risk management strategies.

Ace Therapeutics is dedicated to assisting our clients in advancing their antipsychotic drug development programs by ensuring the safety and efficacy of their medications through our specialized substance abuse and dependence testing services. Should you require further information, please do not hesitate to contact us. We are pleased to assist you.