Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Dizocilpine maleate

Inquiry

Specification

Cat. No.

SMD159

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Dizocilpine maleate

Size

10.0mg; 50.0mg

Price

Inquiry

Availability

2 Weeks

Description

Dizocilpine, also known as MK-801 or (+)-MK-801, is an uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug acts as a potent anti-convulsant and likely has dissociative anesthetic properties, but it is not used clinically for this purpose due to the discovery of brain lesions, called Olney's lesions (see below), in test rats. Dizocilpine is the most frequently used non-competitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.

CAS Number

77086-22-7 (maleate)

Chemical Formula

C20H19NO4

Molecular Weight

337.375

Elemental Analysis

C, 71.20; H, 5.68; N, 4.15; O, 18.97

Synonym

MK-801; MK 801; MK801; MK-801 maleate; Dizocilpine maleate.

IUPAC/Chemical Name

5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate

InChi Key

QLTXKCWMEZIHBJ-BTJKTKAUSA-N

InChi Code

InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code

CC1(N2)C3=CC=CC=C3CC2C4=CC=CC=C14.O=C(O)/C=C\C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.