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Diphenidol-d10

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Specification

Cat. No.

SMD182

Related Diseases

Anxiety

Product Name

Diphenidol-d10

Size

1.0mg

Price

Inquiry

Availability

2 Weeks

Description

Diphenidol-d10 is intended for use as an internal standard for the quantification of diphenidol by GC- or LC-MS. Diphenidol is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.43, 2.8, 1.1, 0.91, and 1.28 µM in CHO cell membranes expressing M1-5 receptors, respectively). It also inhibits Kv channels in Neuro2A cells (IC50 = 28.2 µM), as well as L-type voltage-gated calcium channels in differentiated NG 108-15 cells in a concentration-dependent manner. Microiontophoretic application of diphenidol inhibits rotation-induced firing of medial vestibular nucleus neurons in a cat model of vertigo. Diphenidol (3.2 mg/kg, i.v.) prevents apomorphine-induced emesis in dogs. Formulations containing diphenidol have been used in the treatment of vertigo and as antiemetics.

CAS Number

unknown

Chemical Formula

C21H17D10NO

Exact Mass

319.272

Molecular Weight

319.514

Elemental Analysis

C, 78.94; H, 11.67; N, 4.38; O, 5.01

Synonym

Diphenidol-d10; Diphenidol d10;

IUPAC/Chemical Name

1,1-diphenyl-4-(piperidin-1-yl-d10)butan-1-ol

InChi Key

OGAKLTJNUQRZJU-FNJHSXSFSA-N

InChi Code

InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2/i3D2,8D2,9D2,16D2,17D2

SMILES Code

OC(CCCN1C([2H])(C([2H])(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])[2H])[2H])(C2=CC=CC=C2)C3=CC=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.