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Dihydrokainic acid

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Specification

Cat. No.

SMD792

Related Diseases

Depression

Product Name

Dihydrokainic acid

Size

1.0mg; 5.0mg; 10.0mg; 25.0mg

Price

Inquiry

Availability

2 Weeks

Description

Dihydrokainic acid is an inhibitor of excitatory amino acid transporter 2 (EAAT2). EEAT2 exhibits anti-depressant-like activity --- an effect that is blocked by the AMPA receptor antagonist NBQX and the serotonin (5-HT) receptor subtype 5-HT1A antagonist WAY-100635. It also increases glutamate and serotonin levels and the expression of c-Fos in the dorsal raphe nucleus. It also impairs memory acquisition, consolidation, and retrieval.

CAS Number

52497-36-6

Chemical Formula

C10H17NO4

Exact Mass

215.1158

Molecular Weight

215.249

Elemental Analysis

C, 55.80; H, 7.96; N, 6.51; O, 29.73

Synonym

Dihydrokainic acid, DHK

IUPAC/Chemical Name

(2S,3S,4R)-2-carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid

InChi Key

JQPDCKOQOOQUSC-OOZYFLPDSA-N

InChi Code

InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

SMILES Code

OC([C@@H]1[C@@H](CC(O)=O)[C@@H](C(C)C)CN1)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.