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Dibenzazepine

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Specification

Cat. No.

SMD791

Related Diseases

Depression

Product Name

Dibenzazepine

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg

Price

Inquiry

Availability

2 Weeks

Description

Dibenzazepine, also known as YO-01027 and Iminostilbene, is a potent γ-secretase inhibitor. Dibenzazepine also potently blocks amyloid precursor protein-like (APPL) and Notch cleavage. γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is now being considered as a therapeutic target for a number of diseases. Potent, orally bioavailable γ-secretase inhibitors (GSIs) have been developed and tested in humans with Alzheimer's disease (AD) and cancer.

CAS Number

209984-56-5

Chemical Formula

C26H23F2N3O3

Exact Mass

463.17075

Molecular Weight

463.48

Elemental Analysis

C, 67.38; H, 5.00; F, 8.20; N, 9.07; O, 10.36

Synonym

YO-01027; YO 01027; YO01027; Dibenzazepine; DBZ; Iminostilbene; Deshydroxy LY-411575.

IUPAC/Chemical Name

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

InChi Key

QSHGISMANBKLQL-OWJWWREXSA-N

InChi Code

InChI=1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1

SMILES Code

C[C@H](NC(CC1=CC(F)=CC(F)=C1)=O)C(N[C@@H]2C(N(C)C3=CC=CC=C3C4=CC=CC=C24)=O)=O

Appearance

Yellow to orange solid powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.