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Dexniguldipine (free base)

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Specification

Cat. No.

SMD768

Related Diseases

Depression

Product Name

Dexniguldipine (free base)

Size

Customizable

Price

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Description

Dexniguldipine (free base) is the (+)-enantiomer of the dihydropyridine derivate niguldipine. Dexniguldipine showed a binding affinity to the P-glycoprotein and therefore it is to be assumed to block the P-glycoprotein pumping mechanism and to modulate multidrug resistance. ( NCI)

CAS Number

120054-86-6 (free base)

Chemical Formula

C36H39N3O6

Exact Mass

609.2839

Molecular Weight

609.723

Elemental Analysis

C, 70.92; H, 6.45; N, 6.89; O, 15.74

Synonym

Dexniguldipine (free base);

IUPAC/Chemical Name

( )-(R)-3-(4,4-Diphenylpiperidino)propyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate.

InChi Key

SVJMLYUFVDMUHP-MGBGTMOVSA-N

InChi Code

InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m1/s1

SMILES Code

O=C(C1=C(C)NC(C)=C(C(OCCCN2CCC(C3=CC=CC=C3)(C4=CC=CC=C4)CC2)=O)[C@@H]1C5=CC=CC([N+]([O-])=O)=C5)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.