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Dexmecamylamine HCl

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Specification

Cat. No.

SMD194

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Dexmecamylamine HCl

Size

Customizable

Price

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Description

Dexmecamylamine, also known as TC-5214 and NIH-11008, is a nicotinic channel modulator with antidepressant activity. TC-5214 demonstrated positive effects in a number of animal models of depression and anxiety. TC-5214 was active in the forced swim test in rats (minimum effective dose (MED)=3 mg/kg i.p.), a classical depression model. It was also active in the behavioral despair test in mice (0.1-3.0 mg/kg i.p.), another model of depression.

CAS Number

107596-30-5 (HCl)

Chemical Formula

C11H22ClN

Exact Mass

167.1674

Molecular Weight

203.754

Elemental Analysis

C, 64.84; H, 10.88; Cl, 17.40; N, 6.87

Synonym

TC-5214; TC 5214; TC5214; NIH-11008; NIH 11008; NIH11008; Dexmecamylamine; Dexmecamylamine HCl

IUPAC/Chemical Name

(1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

InChi Key

PKVZBNCYEICAQP-GSTSRXQZSA-N

InChi Code

InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m0./s1

SMILES Code

CC1(C)[C@](NC)(C)[C@]2([H])CC[C@@]1([H])C2.[H]Cl

Appearance

White to off-white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.