Ace Therapeutics offers comprehensive developmental and reproductive assessment (DART) services for antipsychotics. Our expertise in toxicology, behavioral testing, and analytical chemistry enables us to provide high-quality DART studies that deliver reliable results, saving our clients time and money in antipsychotic drug development.

Overview of Developmental & Reproductive Toxicity Assessment Services for Antipsychotics

The developmental and reproductive toxicity evaluation assesses the impact of pharmaceuticals on gonadal morphology and function, the estrous cycle, mating behavior, conception, gestation, delivery, lactation, and postweaning growth and development of the pups. Ace Therapeutics has established a comprehensive developmental and reproductive toxicity assessment program to assist clients in evaluating the effects of potential antipsychotic drugs on the reproductive system and embryonic development. We employ a range of assays, both animal and cellular, to assess the impact of drug candidates on gonadal function, fertility, embryonic development, and offspring health. Furthermore, we utilize a range of advanced research methods and techniques to ensure the safety and efficacy of our drugs, including reproductive hormone analyses, embryological assessments, and genetic analyses. These results provide crucial scientific data for the safety assessment and clinical application of potential antipsychotic drugs. Our experienced team of experts will provide you with customized evaluation solutions to help you meet all regulatory requirements cost-effectively.

Our Developmental and Reproductive Toxicology (DART) Services

Ace Therapeutics' team of experts offers a comprehensive suite of studies to assess developmental and reproductive toxicity potential. Our services primarily include:

• Fertility and early embryonic development: assessing the effects of drugs on fertility and early embryonic development.
• Embryo-fetal developmental toxicity test: detects potential effects of drugs on embryo and fetus development, including malformations and mortality.
• Perinatal toxicity tests: to assess the effects of drugs on the fetus in the perinatal period.
• Prenatal developmental toxicity studies: to assess the effects of drugs on fetal development, including malformations, growth retardation, and metabolic syndrome.
• One generation of reproductive toxicity
• Two-generation reproduction toxicity
• Reproductive/developmental toxicity screening
• Extended one-generation reproductive toxicity study

Our Advanced Technologies

• In vitro cell modeling: Advanced in vitro germ cell, embryonic cell models can effectively assess the toxic effects of drugs on cells.
• Animal models: Validated animal models, such as rats and rabbits, can mimic human physiological responses, especially in reproduction and development.
• Behavioral tests: Validated behavioral tests and visual data analysis software allow real-time monitoring of the effects of the drug on the animal's estrous cycle, mating performance, and fertility.
• Histopathology and chemical analysis techniques: Advanced microanatomy techniques, imaging techniques, computer-assisted sperm evaluation, brain morphometry, chemical analysis, and other techniques ensure the delivery of actionable findings.

Ace Therapeutics is committed to providing efficient and accurate developmental and reproductive toxicity assessment services for antipsychotics to help clients address the challenges of long, complex, and costly DART studies in antipsychotic drug development. By partnering with us, you will cost-effectively minimize your R&D risks and accelerate your time to market. If you are interested in our services or require further information, please contact us.