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Daridorexant free base

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Specification

Cat. No.

SMD1273

Related Diseases

Insomnia

Product Name

Daridorexant free base

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg

Price

Inquiry

Availability

2 Weeks

Description

Daridorexant, also known as Nemorexant and ACT541468, is a new dual orexin receptor antagonist, used in the treatment of Insomnia Disorder in Adult Patients. By specific binding to both orexin receptors, daridorexant inhibits the actions of the wake-promoting orexin (also called hypocretin) neuropeptides. This mechanism avoids a more widespread inhibition of neuronal pathways and associated side effects that are intrinsic to positive allosteric GABA-A receptor modulators. Daridorexant was approved for Adults With Insomnia in Jan 2022.

CAS Number

1505484-82-1 (free base)

Chemical Formula

C23H23ClN6O2

Exact Mass

450.1571

Molecular Weight

450.93

Elemental Analysis

C, 61.26; H, 5.14; Cl, 7.86; N, 18.64; O, 7.10

Synonym

Daridorexant; Daridorexant free base; ACT541468; ACT 541468; ACT-541468; Nemorexant;

IUPAC/Chemical Name

Methanone, ((2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)-

InChi Key

NBGABHGMJVIVBW-QHCPKHFHSA-N

InChi Code

InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1

SMILES Code

O=C(N1[C@](C)(C2=NC3=CC=C(Cl)C(C)=C3N2)CCC1)C4=CC(OC)=CC=C4N5N=CC=N5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

to be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.