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Crinecerfont

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Specification

Cat. No.

SMD173

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Crinecerfont

Size

Customizable

Price

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Description

Crinecerfont, also known as SSR125543, is a potent, selective, and orally active corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively). SSR125543 attenuates long-term cognitive deficit induced by acute inescapable stress in mice, independently from the hypothalamic pituitary adrenal axis. SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction.

CAS Number

752253-39-7 (free base)

Chemical Formula

C27H28ClFN2OS

Exact Mass

482.1595

Molecular Weight

483.04

Elemental Analysis

C, 67.14; H, 5.84; Cl, 7.34; F, 3.93; N, 5.80; O, 3.31; S, 6.64

Synonym

SSR125543; SSR-125543; SSR 125543; SSR125543A; SSR-125543A; SSR 125543A; Crinecerfont

IUPAC/Chemical Name

(S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine

InChi Key

IEAKXXNRGSLYTQ-DEOSSOPVSA-N

InChi Code

InChI=1S/C27H28ClFN2OS/c1-6-11-31(24(13-19-8-9-19)20-10-7-16(2)23(29)14-20)27-30-26(18(4)33-27)21-12-17(3)25(32-5)15-22(21)28/h1,7,10,12,14-15,19,24H,8-9,11,13H2,2-5H3/t24-/m0/s1

SMILES Code

C#CCN([C@H](C1=CC=C(C)C(F)=C1)CC2CC2)C3=NC(C4=CC(C)=C(OC)C=C4Cl)=C(C)S3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.