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Clozapine N-oxide

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Specification

Cat. No.

SMD124

Related Diseases

Anxiety

Related Diseases

Schizophrenia

Product Name

Clozapine N-oxide

Size

10.0mg; 25.0mg

Price

Inquiry

Availability

2 Weeks

Description

Clozapine N-oxide is a metabolite of clozapine, an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models.

CAS Number

34233-69-7 (N-oxide)

Chemical Formula

C18H19ClN4O

Exact Mass

342.1247

Molecular Weight

342.827

Elemental Analysis

C, 63.06; H, 5.59; Cl, 10.34; N, 16.34; O, 4.67

Synonym

Clozapine N-oxide

IUPAC/Chemical Name

3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine

InChi Key

VZPIXQNOPWEUMZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H19ClN4O/c1-23(24)9-7-22(8-10-23)17-4-2-3-15-18(17)21-16-11-14(19)6-5-13(16)12-20-15/h2-6,11-12,21H,7-10H2,1H3

SMILES Code

[O-][N+]1(C)CCN(C2=C3NC4=CC(Cl)=CC=C4C=NC3=CC=C2)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.