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Clobenpropit free base

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Specification

Cat. No.

SMD763

Related Diseases

Depression

Product Name

Clobenpropit free base

Size

Customizable

Price

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Description

Clobenpropit, also known as VUF 9153, is a highly potent H3 antagonist and H4 partial agonist. Clobenpropit has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. Clobenpropit promises neuroprotection against LPS-induced cognitive deficits by meliorating neuroinflammation and restoring the MRCC enzymes in mice. Clobenpropit protects propofol-induced apoptosis of hippocampal neurons through PI3K/AKT pathway.

CAS Number

145231-45-4 (free base)

Chemical Formula

C14H17ClN4S

Exact Mass

308.0862

Molecular Weight

308.83

Elemental Analysis

C, 54.45; H, 5.55; Cl, 11.48; N, 18.14; S, 10.38

Synonym

Clobenpropit (free base); VUF9153; VUF-9153; VUF 9153

IUPAC/Chemical Name

Carbamimidothioic acid, ((4-chlorophenyl)methyl)-, 3-(1H-imidazol-4-yl)propyl ester

InChi Key

UCAIEVHKDLMIFL-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)

SMILES Code

N=C(SCCCC1=CNC=N1)NCC2=CC=C(Cl)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.