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Cerlapirdine hydrochloride

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Specification

Cat. No.

SMD1463

Related Diseases

Schizophrenia

Product Name

Cerlapirdine hydrochloride

Size

Customizable

Price

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Description

Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. As of 2011, it is in phase II clinical trials, and has demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.

CAS Number

925447-04-7 (HCl)

Chemical Formula

C22H24ClN3O3S

Molecular Weight

445.96

Elemental Analysis

C, 59.25; H, 5.42; Cl, 7.95; N, 9.42; O, 10.76; S, 7.19

Synonym

Cerlapirdine hydrochloride; SAM531; SAM 531 SAM-531; PF-05212365; P -05212365; PF05212365; PF-5212365; P -5212365; PF5212365; WAY-262,531; WAY 262,531; WAY262,531

IUPAC/Chemical Name

1-Propanamine, N,N-dimethyl-3-((3-(1-naphthalenylsulfonyl)-1H-indazol-5- yl)oxy)-, hydrochloride (1:1)

InChi Key

RNGAZJUESDPASQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H23N3O3S.ClH/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21;/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24);1H

SMILES Code

O=S(C1=NNC2=C1C=C(OCCCN(C)C)C=C2)(C3=C4C=CC=CC4=CC=C3)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.