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Caudatin

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Specification

Cat. No.

SMD706

Related Diseases

Depression

Product Name

Caudatin

Size

1.0mg; 5.0mg; 10.0mg

Price

Inquiry

Availability

2 Weeks

Description

Caudatin is a C-21 steroid that has been found in C. auriculatum and has anticancer activity. It is cytotoxic to SMMC-7721, MCF-7, and HeLa cells (IC50s = 24.95, 65.82, and 247.54 µM, respectively). Caudatin (50-300 µM) induces apoptosis in and inhibits mammosphere formation by MDA-MB-231 breast cancer cells, as well as decreases the number of cancer stem cells (CSCs) in the MDA-MB-231 cell population. In vivo, caudatin (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model.

CAS Number

38395-02-7

Chemical Formula

C28H42O7

Exact Mass

490.2931

Molecular Weight

490.637

Elemental Analysis

C, 68.55; H, 8.63; O, 22.83

Synonym

Caudatin;

IUPAC/Chemical Name

(3S,8S,9R,10R,12R,13S,14R,17S)-17-acetyl-3,8,14,17-tetrahydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl (E)-3,4-dimethylpent-2-enoate

InChi Key

VWLXIXALPNYWFH-UXGQNDOZSA-N

InChi Code

InChI=1S/C28H42O7/c1-16(2)17(3)13-23(31)35-22-15-21-24(5)9-8-20(30)14-19(24)7-10-27(21,33)28(34)12-11-26(32,18(4)29)25(22,28)6/h7,13,16,20-22,30,32-34H,8-12,14-15H2,1-6H3/b17-13+/t20-,21+,22+,24-,25+,26+,27-,28+/m0/s1

SMILES Code

C[C@@]12[C@@](CC[C@]2(C(C)=O)O)(O)[C@@]3(O)[C@]([H])(C[C@H]1OC(/C=C(C(C)C)\C)=O)[C@]4(C)C(C[C@@H](O)CC4)=CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.