Candidate Identification for Antipsychotics

Candidate Identification for Antipsychotics

Inquiry

Ace Therapeutics provides comprehensive antipsychotic drug candidate evaluation services, including drug metabolism and pharmacokinetics (DMPK), safety and toxicology, bioanalytical and genomics-related services.

Introduction of Candidate Identification for Antipsychotics

The discovery of a lead leads to an intensive search to find a drug-like small molecule or biotherapeutic, often referred to as a development candidate, which will proceed to the preclinical phase and, if successful, to clinical development and ultimately to marketed drugs. The identification of an antipsychotic drug candidate marks the completion of the reciprocal feedback of molecular design, chemical synthesis, and various biological evaluations and the attainment of a new stage of antipsychotic drug development. It also signifies the initiation of greater investment in preclinical, process, and clinical studies.

Fig. 1 Overview of drug discovery screening assays.Fig. 1 Overview of drug discovery screening assays. (Hughes JP, et al., 2011)

Candidate Identification Services

Ace Therapeutics has a world-leading research platform and we are committed to providing services and solutions to research institutions, pharmaceutical and biotechnology companies for the identification of antipsychotic drug candidates. We can initially test the pharmacokinetic and toxicological properties of antipsychotic drug candidates in vitro or in vivo and identify antipsychotic drug candidates with optimal properties to facilitate your antipsychotic drug development process.

Our Drug Discovery Laboratory Services team has the expertise to work with you through all phases of antipsychotic drug development. We believe in providing high-quality services by focusing on technical excellence, which allows us to understand and solve complex scientific challenges (e.g., challenges in drug formulation, data interpretation, and bioanalysis). We employ new scientific methods, technologies, and processes to provide innovative solutions to challenging problems. We are committed to providing rigorous scientific expertise to ensure the highest quality and compliance for each drug discovery project.

Antipsychotic Drug Candidate Identification Services We Can Provide

  • Chemical studies of antipsychotic drugs
  • Computational science services
  • Process scale-up testing of antipsychotic drugs
  • In vitro toxicity studies of antipsychotic drugs
  • In vitro and in vivo antipsychotic efficacy studies
  • Antipsychotic pharmacokinetic studies
  • Identification of other antipsychotic drug candidates

Antipsychotic Drug Candidate Identification Process

  • Detection and evaluation of the activity of optimized antipsychotic leads in vivo and in vitro. Activity refers to general biological activity, including efficacy, pharmacokinetics, and toxicity.
  • Cyclic feedback is used for confirmatory screening of antipsychotic drug leads.
  • Identify antipsychotic drug candidates.

Fig. 2 Antipsychotic Drug Candidate Identification Process.Fig. 2 Antipsychotic Drug Candidate Identification Process.

Ace Therapeutics brings together the right skills, expertise, and discovery platforms to design and deliver new clinical chemistry entities in the field of therapeutic psychiatric disorders. We can provide a complete solution for the entire small molecule drug discovery value chain from hit discovery, hit to lead, lead optimization, preclinical candidates to IND filing. If you are interested in this service, please make an inquiry to learn how we can support you in your project.

Reference

  1. Hughes JP, Rees S, Kalindjian SB, Philpott KL. Principles of early drug discovery. Br J Pharmacol. 2011, 162(6):1239-1249.
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