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BMS-181100 HCl

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Specification

Cat. No.

SMD1409

Related Diseases

Schizophrenia

Product Name

BMS-181100 HCl

Size

Customizable

Price

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Description

BMS-181100, also known as BMY-14802; BMY-14802-1, is a sigma receptor antagonist and a 5-HT1A agonist with antipsychotic effects and potential useful for the treatment of schizophrenia. BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats. BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors. BMY-14802 reverses amphetamine-induced changes in neostriatal single-unit activity in freely moving rats. BMY 14802 increases expression of proneurotensin mRNA in the rat striatum.

CAS Number

105565-55-7 (HCl)

Chemical Formula

C18H23ClF2N4O

Molecular Weight

384.8558

Elemental Analysis

C, 56.18; H, 6.02; Cl, 9.21; F, 9.87; N, 14.56; O, 4.16

Synonym

BMS-181100; BMS181100; BMS181100; BMY-14802; BMY 14802; BMY14802; BMY-14802-1; BMS-181100 HCl; BMS-181100 hydrochloride.

IUPAC/Chemical Name

1-(4-fluorophenyl)-4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)butan-1-ol hydrochloride

InChi Key

NIBVEFRJDFVQLM-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H22F2N4O.ClH/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18;/h3-6,12-13,17,25H,1-2,7-11H2;1H

SMILES Code

OC(C1=CC=C(F)C=C1)CCCN2CCN(C3=NC=C(F)C=N3)CC2.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.