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Bitopertin

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Specification

Cat. No.

SMD1435

Related Diseases

Schizophrenia

Product Name

Bitopertin

Size

50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g

Price

Inquiry

Availability

2 Weeks

Description

Bitopertin, also known as Paliflutine and RG-1678, is a glycine reuptake inhibitor which was under development as an adjunct to antipsychotics for the treatment of persistent negative symptoms or suboptimally-controlled positive symptoms associated with schizophrenia. Bitopertin-mediated glycine reuptake inhibition may represent a novel treatment option for schizophrenia, with the potential to address negative symptoms.

CAS Number

845614-11-1

Chemical Formula

C21H20F7N3O4S

Exact Mass

543.1063

Molecular Weight

543.4568

Elemental Analysis

C, 46.41; H, 3.71; F, 24.47; N, 7.73; O, 11.78; S, 5.90

Synonym

RG-1678; RG1678; RG 1678; R-1678; R1678; R 1678; RO4917838; RO-4917838; RO 4917838; Bitopertin

IUPAC/Chemical Name

(S)-(4-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)(5-(methylsulfonyl)-2-((1,1,1-trifluoropropan-2-yl)oxy)phenyl)methanone

InChi Key

YUUGYIUSCYNSQR-LBPRGKRZSA-N

InChi Code

InChI=1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/t12-/m0/s1

SMILES Code

O=C(N1CCN(C2=NC=C(C(F)(F)F)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3O[C@@H](C)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.