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Bavisant dihydrochloride

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Specification

Cat. No.

SMD002

Related Diseases

ADHD

Product Name

Bavisant dihydrochloride

Size

Customizable

Price

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Description

Bavisant dihydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. Histamine H3 receptors reside on non-histamine neurons and regulate other neurotransmitters (e.g. acetylcholine, noradrenaline [norepinephrine]) suggesting that H3 antagonists have the potential to improve attention and impulsivity. Research indicates that H3 receptor antagonists due to their novel mechanism of action may have a unique treatment effect offering an important alternative for the treatment of ADHD.

CAS Number

1103522-80-0 (HCl)

Chemical Formula

C19H31Cl2N3O3

Exact Mass

419.1742

Molecular Weight

420.37

Elemental Analysis

C, 54.29; H, 7.43; Cl, 16.87; N, 10.00; O, 11.42

Synonym

Bavisant dihydrochloride; JNJ-31001074-AAC; JNJ 31001074-AAC; JNJ31001074-AAC;

IUPAC/Chemical Name

(4-cyclopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone dihydrochloride hydrate

InChi Key

BLFBQJUVAGIUBL-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H27N3O2.2ClH.H2O/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20;;;/h1-4,18H,5-15H2;2*1H;1H2

SMILES Code

O=C(N1CCN(C2CC2)CC1)C3=CC=C(CN4CCOCC4)C=C3.[H]Cl.[H]Cl.[H]O[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.