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Basimglurant

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Specification

Cat. No.

SMD100

Related Diseases

Anxiety

Related Diseases

Schizophrenia

Related Diseases

Depression

Product Name

Basimglurant

Size

Customizable

Price

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Description

Basimglurant, also known as RO 4917523 and RG-7090, is a novel mGlu5 negative allosteric modulator currently in Phase 2 clinical development for MDD and Fragile X syndrome (FXS). Basimglurant is a promising novel medicine for psychiatric diseases. Basimglurant has favorable drug-like properties, a differentiated molecular mechanism of action, and antidepressant-like features which suggest the possibility of also addressing important comorbidities of MDD including anxiety and pain as well as daytime sleepiness and apathy or lethargy.

CAS Number

1034442-21-1 (free base)

Chemical Formula

C18H13ClFN3

Exact Mass

325.0782

Molecular Weight

325.77

Elemental Analysis

C, 66.36; H, 4.02; Cl, 10.88; F, 5.83; N, 12.90

Synonym

RG-7090; RG 7090; RG7090; RO4917523; RO 4917523; RO-4917523; Basimglurant

IUPAC/Chemical Name

2-chloro-4-((1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-yl)ethynyl)pyridine

InChi Key

UPZWINBEAHDTLA-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7,9-11H,1-2H3

SMILES Code

CC1=C(C#CC2=CC(Cl)=NC=C2)N=C(C)N1C3=CC=C(F)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.