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AZD1979

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Specification

Cat. No.

SMD086

Related Diseases

Anxiety

Product Name

AZD1979

Size

Customizable

Price

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Description

AZD1979 is a melanin concentrating hormone receptor 1 (MCHr1) antagonist (Ki MCHr1 (GTP7s) = 5.1 nM; Ki MCHr1 (Binding) -12.1 nM). AZD1979 has excellent DMPK properties and gave robust effects on weight loss when dosed orally in a DIO mouse model. Preclinical GLP tox and safety pharmacology studies were without treatment related findings and 103 was selected as a clinical candidate. MCHr1 knockout (KO) mice are resistant to dietary induced obesity (DIO) mainly due to elevated motor activity and energy expenditure. MCHr1 antagonists have been investigated preclinically as a treatment option for obesity, depression and anxiety disorders.

CAS Number

1254035-84-1

Chemical Formula

C25H26N4O5

Exact Mass

462.1903

Molecular Weight

462.506

Elemental Analysis

C, 64.92; H, 5.67; N, 12.11; O, 17.30

Synonym

AZD1979; AZD-1979; AZD 1979.

IUPAC/Chemical Name

(3-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

InChi Key

BKKPIQPFRAPEAY-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3

SMILES Code

O=C(N1CC(OC2=CC=C(CN(C3)CC43COC4)C=C2)C1)C5=NN=C(C6=CC=C(OC)C=C6)O5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.