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AVL-3288

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Specification

Cat. No.

SMD455

Related Diseases

Autism

Related Diseases

Schizophrenia

Product Name

AVL-3288

Size

5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; Click to view more sizes and prices

Price

Inquiry

Availability

2 Weeks

Description

AVL-3288 is a first-in-class, orally available, small molecule, selective allosteric modulator of the alpha7 nicotinic acetylcholine receptor (α7 nAChR). AVL-3288 has shown preclinical efficacy in rat paradigms of attention and memory, including models of cognitive dysfunction1-3. AVL-3288 evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). AVL-3288 exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

CAS Number

917837-54-8

Chemical Formula

C19H15Cl2N3O2

Exact Mass

387.0541

Molecular Weight

388.248

Elemental Analysis

C, 58.78; H, 3.89; Cl, 18.26; N, 10.82; O, 8.24

Synonym

AVL-3288; AVL 3288; AVL3288; XY-4083; XY 4083; XY4083; Anvylic-3288; UCI-4083; UCI4083; UCI 4083; CCMI.

IUPAC/Chemical Name

(Z)-3-(4-Chloroanilino)-N-(4-chlorophenyl)-2-(3-methylisoxazol-5-yl)prop-2-enamide

InChi Key

VMAKIACTLSBBIY-BOPFTXTBSA-N

InChi Code

InChI=1S/C19H15Cl2N3O2/c1-12-10-18(26-24-12)17(11-22-15-6-2-13(20)3-7-15)19(25)23-16-8-4-14(21)5-9-16/h2-11,22H,1H3,(H,23,25)/b17-11-

SMILES Code

O=C(NC1=CC=C(Cl)C=C1)/C(C2=CC(C)=NO2)=C\NC3=CC=C(Cl)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.