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AR-M1896

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Specification

Cat. No.

SMD065

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

AR-M1896

Size

1.0mg; 5.0mg; 10.0mg

Price

Inquiry

Availability

2 Weeks

Description

AR-M1896 is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50 = 9.32 nM in a fluorescence imaging plate reader assay). It selectively binds to the GAL2 receptor (IC50 = 1.76 nM for the rat receptor) over the GAL1 receptor (IC50 = 879 nM for the human receptor) but does also bind to the GAL3 receptor (Ki = 271 nM for the rat receptor). Intracerebroventricular administration of AR-M1896 (1 nmol/animal) decreases immobility in the forced swim test in rats. It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.

CAS Number

unknown

Chemical Formula

C56H82F3N13O16

Molecular Weight

1250.3422

Elemental Analysis

C, 53.79; H, 6.61; F, 4.56; N, 14.56; O, 20.47

Synonym

AR-M1896; ARM1896; AR M1896; Gal(2-11)-NH2; Gal(2-11)NH2; Gal(2-11) NH2; WTLNSAGYLL-NH2; WTLNSAGYLLNH2; WTLNSAGYLL NH2; Galanin (2-11) amide TFA;

IUPAC/Chemical Name

(S)-2-((S)-2-((2S,3R)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-3-hydroxybutanamido)-4-methylpentanamido)-N1-((2S,5S,11S,14S,17S)-17-carbamoyl-1-hydroxy-11-(4-hydroxybenzyl)-14-isobutyl-5,19-dimethyl-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazaicosan-2-yl)succinamide 2,2,2-trifluoroacetate

InChi Key

ILTGGRBAWMAFAK-DQGGFSSQSA-N

InChi Code

InChI=1S/C54H81N13O14.C2HF3O2/c1-26(2)17-37(46(57)73)62-49(76)38(18-27(3)4)63-51(78)40(20-31-13-15-33(70)16-14-31)61-44(72)24-59-47(74)29(7)60-53(80)42(25-68)66-52(79)41(22-43(56)71)64-50(77)39(19-28(5)6)65-54(81)45(30(8)69)67-48(75)35(55)21-32-23-58-36-12-10-9-11-34(32)36;3-2(4,5)1(6)7/h9-16,23,26-30,35,37-42,45,58,68-70H,17-22,24-25,55H2,1-8H3,(H2,56,71)(H2,57,73)(H,59,74)(H,60,80)(H,61,72)(H,62,76)(H,63,78)(H,64,77)(H,65,81)(H,66,79)(H,67,75);(H,6,7)/t29-,30+,35-,37-,38-,39-,40-,41-,42-,45-;/m0./s1

SMILES Code

N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O.OC(C(F)(F)F)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.