Related Diseases
Depression
Size
100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g; 5.0g
Description
AR-A014418 , also known as SN 4521, is a labeled Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression. AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action. AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons.
Chemical Formula
C12H12N4O4S
Elemental Analysis
C, 46.75; H, 3.92; N, 18.17; O, 20.76; S, 10.40
Synonym
SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII.
IUPAC/Chemical Name
N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea
InChi Key
YAEMHJKFIIIULI-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
SMILES Code
COc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
HS Tariff Code
2934.99.9001