Ace Therapeutics can provide you with gastrointestinal safety assessment services for antipsychotic drugs. We can develop customized plans and implement custom protocols with different endpoints and parameters to meet your specific needs.

The Importance of Gastrointestinal Toxicity Analysis of Antipsychotic Drugs

Side effects of atypical antipsychotics include nausea, vomiting, dry mouth, and dysmotility. Taking antipsychotics causes multiple adverse effects such as constipation in more than half of patients, which is twice the rate of healthy controls. Constipation is a major pattern of impaired gastrointestinal motility, leading to impaired bowel contraction and propulsion. Constipation caused by antipsychotics can lead to intestinal obstruction, ischemic enteropathy, and colonic perforation, and in extreme cases, even to sepsis, aspiration pneumonia, and intestinal perforation. Studies on the gastrointestinal toxicity of antipsychotic drugs can inform and justify the development and improvement of drugs.

Fig. 1 Schematic diagram of the anatomic and histologic organization of the digestive tube. (Gelberg H. 2018)

Gastrointestinal Toxicity Analysis Services

Ace Therapeutics offers a variety of in vitro and in vitro models and analytical methods to evaluate the effects of novel antipsychotic drugs on the gastrointestinal tract. Our in vitro and in vivo models can be used to determine the type and level of toxicity and to identify the cause of any observed pathology. We can rely on our expertise and in-house data on the cellular targets of existing therapeutics to perform appropriate analyses to identify target cell populations, mechanisms of action, and pK/pD responses.

With years of experience in preclinical toxicology studies, we are well-positioned to provide a comprehensive service of in vivo and in vitro testing methods to facilitate our clients' antipsychotic drug research process. Our in vivo and in vitro models include, but are not limited to

Why Choose Us for Gastrointestinal Toxicology Testing?

Our quality control laboratories operate to high standards and are inspected by local regulatory agencies. We offer high-throughput screening and multiplex analysis techniques through our in vitro toxicology laboratory, and we have extensive experience in antipsychotic development.

Our Service Workflow

• One-on-one client consultation
• Preparation of proposals that clearly define project scope, schedule, and cost
• Experiment execution and data analysis
• Preparation of final report

With Ace Therapeutics' extensive experience in high-throughput screening and early-stage antipsychotic drug discovery, we have a deep understanding of drug toxicology analysis. Therefore, we strive to meet your requirements and provide biochemical assays that can reliably measure your target of interest. By thoroughly studying the relevant mechanisms and their influencing factors, we can target and improve the drug to reduce or eliminate adverse effects and improve the efficacy and safety of the drug. If you are interested in this service, please make an inquiry to learn how we can support you in your project.

Reference

1. Gelberg H. Pathophysiological Mechanisms of Gastrointestinal Toxicity. Comprehensive Toxicology. 2018, 139-178.