Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Ansofaxine HCl

Inquiry

Specification

Cat. No.

SMD684

Related Diseases

Depression

Product Name

Ansofaxine HCl

Size

5.0mg; 10.0mg

Price

Inquiry

Availability

2 Weeks

Description

Ansofaxine, also known as toludesvenlafaxine, is a triple reuptake inhibitor, targeting serotonin, dopamine and norepinephrine. Toludesvenlafaxine had high binding affinity on SERT, NET and DAT, and significantly inhibited the reuptake of serotonin (IC50 = 31.4 ± 0.4 nM), norepinephrine (IC50 = 586.7 ± 83.6 nM) and dopamine (IC50 = 733.2 ± 10.3 nM) in vitro. Toludesvenlafaxine demonstrated significant antidepressant-like effects in rat models at 8-16 mg/kg. In addition, toludesvenlafaxine significantly reduced serum corticosterone and significantly increased testosterone levels in rats.

CAS Number

916918-84-8 (HCl)

Chemical Formula

C24H32ClNO3

Molecular Weight

417.974

Elemental Analysis

C, 68.97; H, 7.72; Cl, 8.48; N, 3.35; O, 11.48

Synonym

Ansofaxine HCl; Ansofaxine hydrochloride; Toludesvenlafaxine; LPM570065; LPM 570065; LPM-570065; LY03005; LY-03005; LY 03005;

IUPAC/Chemical Name

4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenyl 4-methylbenzoate hydrochloride

InChi Key

BVWFJKQJRNSYCR-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H31NO3.ClH/c1-18-7-9-20(10-8-18)23(26)28-21-13-11-19(12-14-21)22(17-25(2)3)24(27)15-5-4-6-16-24;/h7-14,22,27H,4-6,15-17H2,1-3H3;1H

SMILES Code

O=C(OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1)C3=CC=C(C)C=C3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.