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Anhydroleucovorin

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Specification

Cat. No.

SMD1374

Related Diseases

Schizophrenia

Product Name

Anhydroleucovorin

Size

1.0mg; 5.0mg; 10.0mg

Price

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Availability

2 Weeks

Description

Anhydroleucovorin, also known as 5,10-Methenyltetrahydrofolate (5,10-CH=THF), is a form of tetrahydrofolate that is an intermediate in metabolism. 5,10-CH=THF is a coenzyme that accepts and donates methenyl (CH=) groups. It is produced from 5,10-methylenetetrahydrofolate by either a NAD+ dependent methylenetetrahydrofolate dehydrogenase, or a NADP+ dependent dehydrogenase. It can also be produced as an intermediate in histidine catabolism, by formiminotransferase cyclodeaminase, from 5-formiminotetrahydrofolate. 5,10-CH=THF is a substrate for methenyltetrahydrofolate cyclohydrolase, which converts it into 10-formyltetrahydrofolate.

CAS Number

7444-29-3

Chemical Formula

C20H21N7O6

Exact Mass

455.1553

Molecular Weight

455.431

Elemental Analysis

C, 52.75; H, 4.65; N, 21.53; O, 21.08

Synonym

Anhydroleucovorin; 5,10-Methenyltetrahydrofolate; 5,10-CH=THF,

IUPAC/Chemical Name

(S)-2-(4-((R)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8-ium-8-yl)benzamido)-4-carboxybutanoate

InChi Key

MEANFMOQMXYMCT-OLZOCXBDSA-N

InChi Code

InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/t12-,13+/m1/s1

SMILES Code

O=C1C2=C(NC(N)=N1)NC[C@]3(N2C=[N+](C3)C4=CC=C(C=C4)C(N[C@@H](CCC(O)=O)C([O-])=O)=O)[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.