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Almorexant

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Specification

Cat. No.

SMD1268

Related Diseases

Insomnia

Product Name

Almorexant

Size

1.0mg; 5.0mg; 10.0mg

Price

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Availability

2 Weeks

Description

Almorexant, also known as ACT-078573, is a competitive receptor antagonist of the OX1 and OX2 orexin receptors. Almorexant selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization.

CAS Number

871224-64-5 (free base)

Chemical Formula

C29H31F3N2O3

Exact Mass

512.2287

Molecular Weight

512.57

Elemental Analysis

C, 67.95; H, 6.10; F, 11.12; N, 5.47; O, 9.36

Synonym

ACT-078573, Almorexant

IUPAC/Chemical Name

(2R)-2-((1S)-6,7-dimethoxy-1-{2-(4-(trifluoromethyl)phenyl)ethyl}-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

InChi Key

DKMACHNQISHMDN-RPLLCQBOSA-N

InChi Code

1S/C29H31F3N2O3/c1-33-28(35)27(20-7-5-4-6-8-20)34-16-15-21-17-25(36-2)26(37-3)18-23(21)24(34)14-11-19-9-12-22(13-10-19)29(30,31)32/h4-10,12-13,17-18,24,27H,11,14-16H2,1-3H3,(H,33,35)/t24-,27+/m0/s1

SMILES Code

CNC(=O)[C@H](N1CCc2cc(OC)c(OC)cc2[C@@H]1CCc3ccc(cc3)C(F)(F)F)c4ccccc4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.