Inquiry

* Name

Phone

* Email

* Services or Products of Interest

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

ADX88178

Inquiry

Specification

Cat. No.

SMD1389

Related Diseases

Schizophrenia

Related Diseases

Anxiety

Product Name

ADX88178

Size

100.0mg; 200.0mg; 500.0mg; 1.0g

Price

Inquiry

Availability

2 Weeks

Description

ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.

CAS Number

1235318-89-4

Chemical Formula

C12H12N6S

Exact Mass

272.0844

Molecular Weight

272.33

Elemental Analysis

C, 52.93; H, 4.44; N, 30.86; S, 11.77

Synonym

ADX-88178; ADX 88178; ADX88178.

IUPAC/Chemical Name

5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine

InChi Key

MIQNXKWDQRNHAU-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)

SMILES Code

CC1=NC(NC2=NC(C3=CNN=C3)=C(C)S2)=NC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.