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ADX71441

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Specification

Cat. No.

SMD060

Related Diseases

Anxiety

Product Name

ADX71441

Size

Customizable

Price

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Description

ADX71441 is a GABAB positive allosteric modulator (PAM). ADX71441 increases urinary latencies and reduces the number of urinary events and the total and average urinary volumes. ADX71441 completely inhibits the micturition reflex and induced overflow incontinence in five out of 10 animals. GABAB PAM has potential as a novel approach for the treatment of overactive bladder. It may also mitigate alcoholism and have analgesic effects in the bladder.

CAS Number

1207440-88-7

Chemical Formula

C19H15ClF2N4O4

Exact Mass

436.075

Molecular Weight

436.8

Elemental Analysis

C, 52.25; H, 3.46; Cl, 8.12; F, 8.70; N, 12.83; O, 14.65

Synonym

ADX71441; ADX 71441; ADX-71441

IUPAC/Chemical Name

N-(5-(4-(4-chloro-3-fluorobenzyl)-6-methoxy-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-2-fluorophenyl)acetamide

InChi Key

BQDMEJYNGXEHSW-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H15ClF2N4O4/c1-10(27)23-16-8-12(4-6-14(16)21)26-19(29)25(18(28)17(24-26)30-2)9-11-3-5-13(20)15(22)7-11/h3-8H,9H2,1-2H3,(H,23,27)

SMILES Code

O=C(C(OC)=NN1C2=CC=C(F)C(NC(C)=O)=C2)N(CC3=CC=C(Cl)C(F)=C3)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.