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A-77636 hydrochloride

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Specification

Cat. No.

SMD042

Related Diseases

Anorexia

Product Name

A-77636 hydrochloride

Size

10.0mg; 50.0mg

Price

Inquiry

Availability

2 Weeks

Description

A-77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist. In a battery of receptor binding assays, A-77636 shows the highest affinity (pKi = 7.40 +/- 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 is an agonist at the dopamine D1 receptors in the fish retina (pEC50 = 8.13; EC50 = 1.1 nM; intrinsic activity = 102% of dopamine) and the rat caudate-putamen (pEC50 = 8.97; intrinsic activity = 134% of dopamine). When tested in marmosets treated with MPTP to induce a parkinsonian-like state, A-77636 increases locomotor activity and decreases the severity of the parkinsonian-like symptoms: the compound is active after either subcutaneous or oral administration.

CAS Number

145307-34-2

Chemical Formula

C20H28ClNO3

Exact Mass

365.1758

Molecular Weight

365.898

Elemental Analysis

C, 65.65; H, 7.71; Cl, 9.69; N, 3.83; O, 13.12

Synonym

A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride

IUPAC/Chemical Name

(1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol Hydrochloride

InChi Key

BWHPNJVKFAPVOG-QYFJGNGUSA-N

InChi Code

InChI=1S/C20H27NO3.ClH/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H/t11?,12?,13?,17-,18-,20?;/m0./s1

SMILES Code

OC1=C(O)C=CC2=C1C[C@@H](C34CC5CC(C4)CC(C5)C3)O[C@H]2CN.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.