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11-Dehydrocorticosterone

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Specification

Cat. No.

SMD083

Related Diseases

Anxiety

Product Name

11-Dehydrocorticosterone

Size

1.0mg; 5.0mg; 10.0mg

Price

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Availability

2 Weeks

Description

11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.

CAS Number

72-23-1

Chemical Formula

C21H28O4

Exact Mass

344.1988

Molecular Weight

344.451

Elemental Analysis

C, 73.23; H, 8.19; O, 18.58

Synonym

11-Dehydrocorticosterone; 11 Dehydrocorticosterone; 11-DHC; 11 DHC; DHCS; Kendall's Compound A; Kendall's Compound-A; NSC 9702; NSC9702; NSC-9702;

IUPAC/Chemical Name

(8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-3,11(2H)-dione

InChi Key

FUFLCEKSBBHCMO-KJQYFISQSA-N

InChi Code

InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1

SMILES Code

C[C@@]12[C@@]3([C@]([H])([C@]4([C@]([C@@H](C(CO)=O)CC4)(C)CC3=O)[H])CCC1=CC(CC2)=O)[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.