Why Is Corneal Tissue Engineering Important?

Corneal disease is one of the leading causes of blindness worldwide. It is estimated that more than 10 million people worldwide suffer from this type of blindness. Corneal transplantation is the gold standard for these diseases. However, the availability of high-quality allogeneic materials derived from human donors is limited and prone to tissue rejection. In order to provide alternatives to the shortage of graftable corneas, the development of living corneal substitutes produced by tissue engineering has been a hot research field in recent years for the treatment of corneal diseases, which can mimic their in vivo counterparts in terms of cell phenotype and tissue structure, so as to achieve the purpose of treating blindness.

Fig. 1. Human cornea structure and function. (Ghezzi CE, et al., 2015)

What Is Ace Therapeutics Doing?

With the advancement of biomaterials, cell culture and tissue engineering technology, corneal tissue engineering has made great progress in the treatment of corneal blindness. In order to change the current situation of shortage of high-quality corneal donors, Ace Therapeutics is committed to finding corneal scaffold materials with good biocompatibility, high safety and good biomechanical properties.

Ace Therapeutics has a team of experienced experts whose expertise spans multiple disciplines including ophthalmology, biomaterials, histology and cytology. Ace Therapeutics is proud of its commitment to developing novel therapies for corneal tissue engineering , aiming to bring light to the world.

What Does Ace Therapeutics Offer?

A major challenge in corneal tissue engineering and corneal transplantation today is to develop synthetic scaffolds that mimic the optical and mechanical properties of the native cornea as highly innervated and vascular tissue. At Ace Therapeutics, you can work with our talented scientists to explore the potential of unknown corneal materials, including biomaterials, natural polymer materials, and synthetic polymer materials. Our experienced scientists can provide the following services to improve your project's chances of success, including but not limited to.

• Corneal Stroma Material Development Services
• In Vitro Corneal Tissue Model Development Services

Advantages of Tissue-Engineered Cornea Development Services

• Provide end-to-end development services, from the early discovery of corneal tissue materials to the later characterization in preclinical living animal models.
• Provide a wide range of corneal stroma materials discovery services, including decellularized porcine cornea, rabbit corneal stroma, animal-derived collagen and other polymers, etc.
• Comprehensive and reliable corneal tissue models, including two-dimensional (2D) models and advanced three-dimensional (3D) models of the cornea.
• Professional advice from our corneal tissue engineering scientists.

Thanks to our strong expertise in corneal tissue engineering and highly qualified researchers, Ace Therapeutics provides end-to-end tissue-engineered cornea development services to clients worldwide. Our expert team not only provides high-quality corneal tissue material development services, but also provides in vitro corneal tissue model development services to meet any of your research needs. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Guérin LP, Le-Bel G, Desjardins P, et al. The Human Tissue-Engineered Cornea (hTEC): Recent Progress. Int J Mol Sci. 2021 22(3):1291.
2. Ghezzi CE, Rnjak-Kovacina J, Kaplan DL. Corneal tissue engineering: recent advances and future perspectives. Tissue Eng Part B Rev. 2015 ;21(3):278-87.

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