Accelerate Your Progress With Translational Biomarker Strategies

Translational biomarkers are used to identify the effects of new therapies or compounds on organs or tissues before clinical effects are evident. Ace Therapeutics is proud to be able to provide you with comprehensive ocular translational biomarker services preclinically. Our ocular translational biomarker services can help you predict subject response preclinically and help you maximize the success of your clinical trials. Assessment of tissue-based biomarkers is integral to the interpretation, translation and prediction of drug response from preclinical to experimental studies.

How We Can Help You?

Ace Therapeutics provides a full range of insights to drive your decision-making, from initial feasibility and development to advanced validation, testing and production. In addition, our team can assist you with late-stage qualification, method validation and implementation to seamlessly transition into the clinical environment. Our solutions include but are not limited to:

• Target Expression Analysis Services

Ace Therapeutics has a team of experts experienced in tissue microarrays (TMA) to screen clients for tissue types available for target expression.

• Translational Biomarker Assessment Services

Translational biomarkers can demonstrate early pharmacodynamic readouts or toxicity signatures in tissues to better guide dose setting in late-stage trials. Our services help clients quantify biomarker IHC staining cell-by-cell in preclinical model tissues to identify the best biomarkers to evaluate in clinical trial tissue samples.

• Services for Stratification of Research Objects

Ace Therapeutics can quantify changes in marker expression across tissues or within specific regions of interest by mechanism-specific readouts to provide disease-type data to guide therapeutic targeting.

• Model Screening Services

Biomarkers and target IHC staining may vary between models and species. Depending on the project needs of the client, Ace Therapeutics will select the appropriate eye disease model to evaluate the efficacy of the molecule. We will then guide the clinical trial.

Explore Our Capabilities

• Immunoassay/LBA
  Custom immunogenicity assays.
  Multiple and specialized platform analyses.
  Microfluidics-based ELISA.
  Kit-based immunoassays.
  Immunoassay automatic analyzer.
• Cell-Based Assays
  High-parameter immunophenotyping of blood, PBMC and tissue.
  In vitro pharmacology.
  Immunotoxicology of cytokine release.
  Cellular immunology.
  Cell-based assays (including ADCC, CDC, proliferation, apoptosis, viability, and more).

Ace Therapeutics is an experienced partner in the field of ophthalmology. We can provide comprehensive ocular translational biomarker analysis services, and advance your discoveries through the use of precision technology. Working with us, you'll get trusted results and a structured transition to the next milestone. If you are interested in our services, please feel free to contact us. We will help you solve all possible challenges during ocular translational biomarker research.

• Omics-Based Ocular Biomarker Discovery and Analysis Services
• Ocular Matrix Biomarker Discovery and Analysis Services
• Ocular Imaging Biomarker Services
• Ocular Predictive Biomarker Identification Services
• Ocular Prognosis Biomarker Services
• Ocular Pharmacodynamic Biomarker Services
• Custom Ocular Biomarker Development Services

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• * All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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