Introduction

Successful clinical development of drug candidates requires safe and effective dosing regimens. Candidate drugs must be able to distribute to the site of action and have sufficient duration of pharmacological response and acceptable safety. Pharmacological studies have been conducted worldwide for decades as part of the nonclinical evaluation of pharmaceuticals for human use. Since pharmacological response is a function of the affinity of the drug for the molecular target and the determinants of drug distribution to the target, pharmacodynamic characteristics are important considerations when defining dosing regimens. In vivo safety pharmacology studies should be designed to precisely define the dose-response relationship of observed adverse reactions.

Services Overview

As a specialist leader in ocular pharmacology models, Ace Therapeutics can help you evaluate the efficacy of your drug product candidates. Pharmacological models can differentiate formulations, active pharmaceutical ingredients, or device iterations. This enables you to select the most effective products to advance development. Ace Therapeutics offers more than a dozen non-clinical animal efficacy models to mimic conditions in the human eye, each specifically designed to evaluate the therapeutic effect of an ophthalmic disease state, condition, or surgical intervention. We use state-of-the-art ophthalmic techniques-including confocal microscopy, tomography, electroretinography, and more-to demonstrate the efficacy of specific ophthalmic drugs.

Explore Our Ophthalmic Disease Model Systems

• Inflammation of the anterior chamber (rabbit).
• Choroidal neovascularization (rodents and pigs)
• Corneal wound healing (Rabbit)
• Experimental autoimmune and endotoxin-induced uveitis (rat, rabbit).
• Oxygen-induced retinopathy in mice.
• Sodium iodate-induced retinal degeneration in mice.
• AAA-induced chronic retinal neovascularization (rabbit) .
• VEGF-induced retinal leakage and neovascularization (rabbit).
• Phacoemulsification (Rabbit)
• Allergic Conjunctivitis (Guinea Pig)
• Normotension/Glaucoma (Rat, Rabbit, Dog)
• Corneal transplant (rabbit)
• Dry eye (mice, rats)
• DMEK/DSEK surgical model (Rabbit)
• Targeted drug/device delivery (subretinal, IVT, IC, subconjunctival)

Pharmacodynamics (PD) is the study of the physiological and biochemical effects of drugs, especially drugs, and discovering how drugs affect the body. Pharmacodynamics places particular emphasis on the dose-effect relationship, that is, the relationship between drug concentration and drug efficacy. In addition to the above, Ace Therapeutics can also determine the dosage and duration of action for clinical use through eye pharmacology and pharmacodynamic experiments.

What attracts our customers is that the dozens of eye disease models we have established can well simulate human eye diseases, so as to predict human clinical and adverse reactions to drugs. This helps our customers to carry out further clinical trials.

Ace Therapeutics offers a wide variety of standard disease models for our global customers' small molecule targeted drug development in ophthalmology. Drawing on years of experience and outstanding expertise in the fields of pharmacology and pharmacodynamics research, our scientists are proud to help you identify the most appropriate disease model for your research interests. You can also explore our extensive and broad-based animal model library to find the model you need. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

• In Vitro Safety and Pharmacology Services
• In Vitro ADME Services
• Early Ocular Toxicology Services
• Ocular Pharmacokinetic (PK) Services

• * Name:
• Phone:
• * Email:
• * Services or Products of Interest:
• Project Description:
• * All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

  * Tick to confirm the Research Use Only (RUO) statement.

• Submit