Importance of Ocular Pharmacokinetic Study

The complex anatomy and dynamic physiological barrier of the eye make it a significant challenge to determine the pharmacokinetic parameters of ocular tissue. Ocular pharmacokinetic studies are a key component of drug development mainly because: 1) Understanding how drugs are absorbed, distributed, metabolized, and eliminated in the eye can better predict the pharmacological effects of drugs on ocular tissue and develop effective treatments for various ocular diseases and conditions. 2) It provides information on how the drug is metabolized and eliminated from the eye. This helps to identify potential toxicity and side effects of drugs, adjust drug dosage, reduce adverse reactions, and improve patient safety. 3) Develop effective drug formulations for ocular diseases. Researchers can optimize drug delivery systems such as eye drops, ointments, or implants by studying the distribution and absorption of drugs in various ocular tissues. 4) Understanding barriers to drug delivery to the eye to develop novel drug delivery systems that overcome these barriers, such as nanoparticle-based drug carriers or slow-release implants. 5) Facilitating personalized medicine by understanding inter-individual variability in drug absorption, distribution, metabolism, and elimination.

Fig. 1. Schematic illustration of the main structure of the eye and the ocular barriers. (Agrahari V, et al., 2016)

Service Overview

As an expert in preclinical ophthalmic pharmacology, toxicology, and pharmacokinetics, Ace Therapeutics is committed to providing our clients with various preclinical ophthalmic pharmacokinetics, pharmacodynamics, and biodistribution research services.

Ocular pharmacokinetics, the assessment of drug absorption in relation to time and dose of administration, is a critical factor in selecting early-stage compounds and evaluating drug candidates for entry into clinical trials. At Ace Therapeutics, our preclinical ocular pharmacokinetics department has several professional scientists with extensive theoretical knowledge and experimental experience, responsible for experimental design, implementation, bioanalysis, and data analysis. We are pleased to provide early ocular pharmacokinetic studies for your ophthalmic product development.

• Early ocular pharmacokinetic studies are an important part of drug discovery. Our research team can help you carry out pharmacokinetic research as early as possible at the early stage of new drug development to evaluate the various characteristics of compounds, so as to improve the efficiency of new drug development and reduce the risk of failure at the later stages of development.

It is worth mentioning that our ocular PK studies can be extended to pathological conditions in preclinical models of ocular diseases to obtain pharmacodynamic/pharmacokinetic (PD/PK) readouts, providing you with information on drug absorption and elimination during disease. Our entire assessment and analysis model will be flexibly designed to meet your specific needs from early drug discovery to first-time drug filing.

What Species do We Work With?

• Mouse
• Rat
• Guinea pig
• Rabbit
• Canine
• Pig
• Mining pig
• Non-human primate (NHP)

Our Routes of Administration

• Topical
• Intracameral
• Intrascleral
• Intrastromal
• Intravitreal injection
• Ocular application
• Periocular injection
• Retrobulbar
• Subconjunctival injection
• Subretinal
• Subtenon
• Systemic routes
• Trans-scleral
• Implant or device

Sample Collection and Analysis

Our Experience in Administrating Formulations

• Liquid
• Suspension
• Lotion
• Ointment
• Gel
• Implants
• Nanoparticle formulation
• Gene therapy vector
• Osmotic pumps
• Patches
• ...

With strong professional knowledge and an advanced technology platform, Ace Therapeutics provides comprehensive ocular pharmacokinetic services. Our professional ocular pharmacokinetic study team will evaluate your ophthalmic products by flexibly designing customized protocols according to your project needs. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Agrahari V, Mandal A, Agrahari V, et al. A comprehensive insight on ocular pharmacokinetics. Drug Deliv Transl Res. 2016, 6(6):735-754.
2. Del Amo EM, Rimpelä AK, Heikkinen E, et al. Pharmacokinetic aspects of retinal drug delivery. Prog Retin Eye Res. 2017, 57:134-185.

• Ocular Toxicology Services
• Ocular Pharmacology Services
• Ocular Histology and Histopathology Services
• Customized Non-GLP Ophthalmic Program Development Services
• Customized Services for Ocular Drug Delivery System Development

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• * All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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