Importance of Ocular Histopathology Assessment

The eye is a very complex structure consisting of the eyeball and its auxiliary structures, which are critical for vision. Ocular histopathology, the study of eye-related diseases, is important in providing critical insights into the underlying causes of ocular diseases and conditions, especially in the drug discovery process. This is mainly due to:

1) Ocular histopathology assessment can help determine the safety of a drug compound by identifying any potential ocular toxicity.

2) Ocular histopathology assessment can help evaluate the efficacy of drugs by examining their effects on ocular tissues, thereby developing effective treatments for various eye diseases.

3) Ocular histopathology assessment reveals the potential mechanism of action of the drug by identifying any changes or changes in the eye tissue after drug treatment, thereby gaining insight into the potential therapeutic target of the drug and the pathways involved.

4) Ocular histopathology assessment enables researchers to compare the effects of different drug candidates or treatment regimens on ocular tissue. This can identify potential side effects or differences in efficacy, helping to select the most promising drug candidates for further development.

5) Regulatory compliance and ocular histopathology assessment are part of the preclinical safety assessment of a drug, which helps to ensure that the drug meets the necessary safety standards before entering clinical trials.

Service Overview

Ace Therapeutics has a dedicated research team of ocular pathologists experienced in evaluating ocular histopathology studies in most animal species commonly used in preclinical ocular toxicity and ocular pharmacodynamic testing. Here, you can collaborate with our pathology experts to advance your ophthalmic product development.

Access Our Ocular Ocular Histology and Histopathology Services

Our ocular histopathology services involve consultation on study design, advice on animal models, and examination and processing of tissue samples, key areas include but are not limited to:

• Histopathological Analysis

• Collection of ocular tissue samples and accessories.
• Preparation of ocular specimens and diagnostic histopathological evaluation.
• A variety of histochemical staining of eye slices.

• Microscopy Analysis

• Tools: Transmission electron microscope (TEM), scanning electron microscope (SEM), atomic force microscope (AFM), etc.
• Examination of intracellular structures, such as organelle assessment.

• Immunohistochemical Analysis

• Visualization and morphological analysis of engrafted or transformed cells in ocular target tissues.
• Assess tissue response to various drug treatments for proof-of-principle and efficacy and safety assessments.

• Molecular Pathology Analysis

• Tools: polymerase chain reaction (PCR), methylation-specific PCR, in situ hybridization, semi-quantitative and quantitative PCR for mRNA and miRNA expression analysis, western blot, and mutation analysis.
• Accurately identify cells in tissues and correlate gene expression with tissue histomorphology, thereby obtaining valuable functional genomics information.

• Impression Cytology Analysis

• Diagnosis of dry eye, corneal, conjunctival tumors, and ulcerative eyelid lesions.

Our Core Capabilities

• Provide pathological opinions on animal models and human spontaneous eye diseases throughout the process.
• Support slide preparation, including paraffin, plastic, EM, and immunohistochemistry.
• Receive and process wet tissue for light microscopy, IHC, transmission, and scanning electron microscopy.
• Full range of consulting services regarding proper fixation and processing for ocular tissues.

Thanks to strong professional knowledge and an advanced technology platform, Ace Therapeutics provides comprehensive ocular ocular histopathology services. Our professional ocular histopathology expert team can create a sound plan for your ocular pathology study. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

• Ocular Toxicology Services
• Ocular Pharmacology Services
• Ocular Pharmacokinetic Services
• Customized Non-GLP Ophthalmic Program Development Services
• Customized Services for Ocular Drug Delivery System Development

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• * All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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