Preclinical Ophthalmic Drug Development Services ace

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* Services of Interest: Ocular Biospecimen Services
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* All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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Ocular Biospecimen Services

Biospecimen analysis refers to the quantitative assessment of target analytes in biological matrices utilizing advanced analytical techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), ligand-binding assays (LBAs), and polymerase chain reaction (PCR). The analysis of ocular biospecimens is a critical part of ophthalmic drug development, impacting candidate prioritization and safety evaluation. At Ace Therapeutics, we provide customized ocular biospecimen analysis solutions that meet the stringent requirements of preclinical and translational research.

Importance of Ocular Biospecimen Analysis

Analysis (e.g., aqueous humor, vitreous fluid, retinal tissues) is pivotal in drug development for several reasons: 1) It determines drug exposure in ocular target organs, elucidates local pharmacological or toxicological effects, and advances the development of new ophthalmic drugs. 2) It analyzes the distribution and concentration of various drug delivery systems in the eye, optimizing delivery methods to enhance drug efficacy and safety. 3) It monitors drug concentration in ocular tissues, ensuring therapeutic effectiveness and safety while minimizing the risk of potential toxicity.

Fig. 1. The anatomical structure of human eye. Fig. 1. Anatomy of the human eye. (Heinig K, et al., 2017)

Access Our Ocular Biospecimen Services

Ocular biospecimen analysis is integral to preclinical research, offering vital insights into eye diseases. Ace Therapeutics provides ocular biospecimen services to assist our clients in elucidating ophthalmic disease mechanisms, identifying new ocular biomarkers, and evaluating potential therapies for eye diseases. Customized biospecimen collection and analysis lie at the core of our ocular biospecimen services, encompassing a diverse range of biological sample types such as ocular biofluids, ocular tissues, whole blood, serum, and plasma.

Biospecimen Collection

Our experts are capable of collecting ocular biofluids (e.g., aqueous humor) and tissues (e.g., cornea) from both normal and disease models. We provide various ocular biospecimens to meet different research needs, supporting ophthalmic drug development.

	Ocular Biofluids	Ocular Tissues
Biospecimens	Tears Aqueous humor Vitreous humor Whole blood Plasma Serum	Intact eye Cornea Lens Iris ciliary body Retina Vitreous body Choroid Sclera Conjunctiva Optic nerve Optic nerve head
Animal Species	Mouse Rat Rabbit Canine Mini pig Non-human primate (NHP)

Ocular Bioanalysis

Our team of scientists is committed to developing highly sensitive and specific bioanalytical methods for different types of ophthalmic drugs and complex biological matrices. Leveraging our professional detection instruments and analysis platforms, we support small molecule and large molecule bioanalysis in ocular biospecimens for drug quantification, ocular biomarker evaluation, and immunogenicity assessments.

Analytical Techniques	Analyte Types	Ocular Bioanalytical Assays
Immunogenicity assay LBA Cell-based assay Enzyme-linked immunospot (ELISPOT) Flow cytometry Chromatography Mass spectrometry	Small molecule Small nucleic acid Peptide Oligonucleotide Gene Protein Antibody Delivery vector	Concentration analysis Quantitative analysis Immunogenicity analysis Functional analysis Ocular biomarker analysis In vitro melanin binding analysis

With strong expertise and an advanced technology platform, Ace Therapeutics provides comprehensive ocular biospecimen services. Based on your specific needs, we can analyze drugs, metabolites, and proteins in various ocular biospecimens to support your drug development projects. If you are interested in our services or need more detailed information, please feel free to contact us.

Reference

Heinig K, Bertran E, Potter J, et al. Ocular bioanalysis: challenges and advancements in recent years for these rare matrices. Bioanalysis. 2017, 9(24):1997-2014.

For Research Use Only.