About Ocular Metabolomics

Metabolomics enables qualitative and quantitative detection of modified pathophysiological stimuli or all low-molecular-weight metabolites, and real-time capture of comprehensive analytes that characterize human phenotypes and their complex metabolic processes. Ocular metabolomics is one of the "omics" strategies following eye genomics, eye proteomics, and eye transcriptomics, which quantitatively and qualitatively assess metabolites by combining bioinformatics and high-throughput analysis strategies (relevant intermediates and final products of metabolism). As one of the latest "omics" sciences, metabolomics is an invaluable part of systems biology, which aims to provide countermeasures for the comprehensive analysis and evaluation of low-molecular-weight compounds in complex biological contexts. In general, an ocular metabolomics protocol includes sample collection, sample preparation, data acquisition, and data analysis. The development and research of ocular metabolomics can help to further accelerate the discovery of new potential biomarkers in the field of ophthalmology.

Fig. 1. Metabolomic workflow. (Du X, et al., 2022)

Our Services

As a comprehensive ophthalmic solutions company, Ace Therapeutics is committed to discovering and analyzing potential biomarkers in relevant samples through metabolomics. This includes tears, vitreous humor, aqueous humor, retina and other matrices.

At Ace Therapeutics, our scientists have developed a comprehensive ocular metabolomics analysis platform based on metabolite coverage, utilizing LC-MS, GC-MS, NMR and other techniques to detect the dynamic changes of all small molecule metabolites related to ocular matrix metabolism before and after cell stimulation or interference, and perform qualitative and quantitative analyses. Helping customers identify potential biomarkers faster and designing and developing individualized custom projects.

Ace Therapeutics' research team has rich experience in bioinformatics analysis, providing one-stop services from pre-sample processing to post-data analysis.

Services Process

• Sample Collection: Including tears, vitreous, aqueous humor, retina, and other biological fluids.
• Sample Preparation: Including extraction, separation and purification of metabolites.
• Data Acquisition and Analysis: Targeted and non-targeted metabolomics analysis of samples was performed by LC-MS.
• Ocular Biomarker Identification: Discovery and screening of ocular metabolism biomarkers for potential use in disease diagnosis or drug discovery.
• Bioinformatics Analysis.

What Can We Provide?

• Ocular stroma sample preparation.
• Untargeted ocular metabolomics analysis.
• Targeted ocular metabolomics DIMS analysis.
• Biomarkers analysis.
• Unknown metabolite identification.
• Exogenous metabolite analysis service.
• Bioinformatics analysis of ocular metabolomics.
  Metabolome enrichment and pathway analysis.
  Principal component analysis.
  OPLS-DA analysis.
  PLS-DA analysis.

Our Advantages

• Rich experience in metabolomic and biomarker analysis.
• Unique comprehensive service for ocular biomarker research.
• Excellent research team.
• Comprehensive research platforms.

Ace Therapeutics' team is dedicated to serving global customers. Our scientists are always ready to provide high-quality metabolomics-based ocular biomarker discovery and analysis solutions to global customers. If you have questions about the content of this service, please feel free to contact us. We look forward to hearing from you.

Reference

1. Du X, Yang L, Kong L, et al. Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy. Front Endocrinol (Lausanne). 2022;13:1037164.

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