What Is A Mechanism of Action Study?

Mechanism of Action (MOA) is a biochemical reaction that occurs in the cell membrane, inside or outside the cell, and can be classified as receptor-mediated or non-receptor-mediated according to the difference between the molecular target and the target-site binding substance (such as a receptor, enzyme or ion channel). MoA studies are a must for small molecule drug development by studying the biochemical reactions that lead to their pharmacological effects to gain a deeper understanding of molecular targets and to identify proteins and activate pathways in the presence of small molecules. With the deepening of ophthalmology research, more and more novel molecules with novel mechanisms of action (MOA) are being developed by researchers for the treatment of ophthalmic diseases (such as cataract, dry eye, glaucoma and retinopathy of prematurity). MOA studies allow scientists to determine how cells will respond to drug compounds that treat specific eye diseases and develop new drugs with similar interactions.

Fig. 1. Mechanism of action (MOA) of lifitegrast at the cellular level. (Perez VL, et al., 2016)

Services Overview

Elucidating a compound's mechanism of action (MOA) is a challenging task in the drug discovery process, and scientists at Ace Therapeutics conduct research early in the selection of small molecule lead series. Our team of scientists uses this information for target identification and validation for target-specific inhibition of many cellular substrates such as signaling kinases. Additionally, we use this information to prioritize hit-to-first-in-work series and drive the hit discovery process.

Ace Therapeutics' MOA Study Services

Ace Therapeutics has an unparalleled team of experts to support you throughout ophthalmic small-molecule drug development process to gain insight into the MOA of compound molecules and accelerate the identification and validation of drug targets. We structural scientists utilize NMR and crystallography to characterize compound binding at the structural level and elucidate how and where compounds interact with target proteins. In addition, various techniques such as classical enzymatic methods, kinetic and biophysical methods, and structural biology are used by our scientists to gain insights into the mechanism of action of compounds. We provide the following mechanisms of action research services for global customers' ophthalmic small molecule drug development including, but not limited to.

Why Choose Us?

MOA studies play an unparalleled role in the small-molecule drug development process, helping to find optimal dosages and minimize the deleterious effects of drug compounds. Ace Therapeutics has a top-level research team to serve clients worldwide with custom proprietary assay development and optimization for their ophthalmic therapeutic MOA studies. The following are the things that attract our clients:

• Provide comprehensive MOA research and analysis services with unrivalled value and turnaround time.
• In vitro and in vivo MOA study protocol development and analysis.
• Comprehensive quantitative or qualitative MOA study analysis.
• Covering the whole process of drug discovery, from early target ID and verification to late clinical safety determination.

Ace Therapeutics provides the highest level of mechanism-of-action research services for your ophthalmic product development. Our talented scientists provide you with support throughout the small molecule drug development process, accelerating your product to easily step into the clinical stage. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

Reference

1. Perez VL, Pflugfelder SC, Zhang S, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016;14(2):207-15.

• RNAi-Based Target Screening
• Computer-Aided Target Identification and Verification
• Gene Expression Profiling-Based Screening
• Genetic Engineering-Based Target Screening
• CRISPR/Cas9-Based Target Screening
• Label-Free Target ID
• Target Functional Annotation and ID
• Target Structure Determination

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