About Ocular Lipidomics

Lipidomics is an emerging and promising field that analyzes different lipid molecules in biological samples. It is considered a branch of metabolomics and is defined as the comprehensive analysis of metabolites in biological samples. Lipids play critical roles in many physiological pathways and can serve as biomarkers of disease or as therapeutic targets to treat disease. The main lipidomics strategies are shotgun lipidomics and liquid chromatography coupled to mass spectrometry. In ophthalmology, a growing number of studies have used lipidomics to analyze potential biomarkers such as lipid mediators that regulate ocular inflammatory responses and tissues (arachidonic acid, eicosapentaene, acid and docosahexaenoic acid, prostaglandins, leukotrienes and hydroxy fatty acids, etc.), lipid mediators in the tear film (cholesterol esters, wax esters, triacylglycerides, diacylglyceride, etc.). In this case, based on lipidomics research enables better understanding of ocular diseases and development of novel biomarkers for early detection and diagnosis, treatment, progression and prognosis.

Fig. 1. Figure 1. Representation and lipid composition of the human tear film. (Khanna RK, et al., 2022)

Our Services

As an industry leader in the field of ophthalmology, Ace Therapeutics has successfully developed a technology platform based on lipid composition analysis. Ace Therapeutics' scientists use shotgun lipidomics and liquid chromatography coupled with mass spectrometry to detect lipid mediators related to ocular diseases, and conduct qualitative and quantitative research to help global customers with their projects.

At Ace Therapeutics, our scientists have decades of experience in lipidomics and ophthalmology research. They are committed to providing support for global customers' ocular biomarker discovery through lipidomics, and designing and developing personalized projects.

Ace Therapeutics' team has rich experience in bioinformatics analysis and provides one-stop services from sample pre-processing to data post-analysis.

Explore our Service Process

• Sample acquisition, including tears, vitreous humor, aqueous humor, retina and other matrices.
• Extraction for separating analytes and reducing matrix effects by removing contaminants, this step is mainly performed by liquid-liquid extraction or/and protein precipitation.
• Composition analysis by reverse phase high resolution mass spectrometry (HPLC-MS) or/and direct infusion mass spectrometry (DI-MS).
• Bioinformatics analysis.
• Discovery and verification of potential biomarkers.

Types of Ocular Lipids We Can Analyze

• Cholesterol esters
• Wax esters
• Triacylglycerides
• Diacylglycerides
• Free cholesterols
• Empty cell
• Sphingomyelins
• C8-glucosylceramide
• 4Glcβ-Cer
• C17-sphingosine-1-phosphate
• Phospholipids
• Phosphatidylcholines
• Phosphatidic acids
• Phosphatidylglycerols
• Lyso-bisphosphatidic acids
• Empty Cell
• Other lipids
• (O-Acyl)-ω-Hydroxy Fatty Acids
• Cholesteryl Sulfates
• Acylcarnitines
• Other lipids

Our Advantages

• Rich experience in lipidomics and biomarker analysis.
• Unique comprehensive service for ocular biomarker research.
• Excellent research team.
• Comprehensive research platforms.

Ace Therapeutics' goal is to provide the most professional service to our global customers. Our scientists are always ready to provide high-quality lipidomics-based ocular biomarker discovery and analysis solutions to global customers. If you have questions about the content of this service, please feel free to contact us. We look forward to hearing from you.

Reference

1. Khanna RK, Catanese S, Emond P, et al. Metabolomics and lipidomics approaches in human tears: A systematic review. Surv Ophthalmol. 2022;67(4):1229-1243.

• Proteomic-Based Ocular Biomarker Discovery and Analysis Services
• Genomics-Based Ocular Biomarker Discovery and Analysis Services
• Metabolomics-Based Ocular Biomarker Discovery and Analysis Services
• Epigenomic-based Ocular Biomarkers Discovery and Analysis Services
• Ocular Cell Biomarker Discovery and Analysis Services
• Ocular Tissue Biomarker Discovery and Analysis Services

• * Name:
• Phone:
• * Email:
• * Services or Products of Interest:
• Project Description:
• * All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

  * Tick to confirm the Research Use Only (RUO) statement.

• Submit