Importance of In Vitro ADME Studies

In the early stages of drug discovery, it is important to understand the key physicochemical properties and structural motifs for the efficacy and safety of candidate compounds. In vitro ADME is used to determine the properties of absorption, distribution, metabolism and excretion. ADME assays are critical for gaining insight into metabolism and potential drug interactions. Therefore, understanding drug-drug interactions and determining the ADME properties of compounds is a critical step for drug development companies.

Services Overview

ADME aims to describe the behavior of drugs in the human body. By focusing on ADME data, Ace Therapeutics' expert team can improve the properties of lead compounds, predict compounds with good binding affinity, and select highly developable candidates with good bioavailability and safety profiles. Whether you are in the early stages of discovery or preparing to submit a new drug application (NDA), Ace Therapeutics offers comprehensive in vitro services to provide you with the quality data you need to understand the disposition and optimization of new chemical entities (NCEs). The following small molecule compounds provide the following testing services.

Physicochemical Characterization

The physical and chemical properties of drugs include ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds is fundamental to the development of pharmaceutical formulations. Ace Therapeutics has extensive knowledge and experience in characterizing biopharmaceuticals. Our expertise gives us valuable insight into formulation development and ADMET assays. Our physicochemical characterization services include:

• Water soluble
• Lipophilic
• Stability

Drug Delivery

• Delivery routes: dedicated ocular routes (intravitreal, subretinal, suprachoroidal, intracameral, subconjunctival).
• Species: rodent, non-rodent.

In Vitro Metabolism Studies

After a drug enters the body for a certain period of time, it will be eliminated through excretion or metabolism into one or more metabolites. Metabolism usually occurs in the liver by a family of CYP enzymes, and drug metabolism in vitro is usually measured by the activity of enzymes contained in the cytochrome CYP450 superfamily. Ace Therapeutics offers CYP response phenotyping services as well as extrahepatic tissues such as intestine, kidney, lung or skin. These assays are performed using a variety of available enzyme sources and analyzed using our high-quality UPLC/HR-MS instruments. Our services include:

• Metabolite Analysis and Identification
• Metabolic Stability Assay
• Extrahepatic Metabolism
• Reactive Metabolite Analysis
• Medicine Interactions

Based on our advanced technology and strong R&D team, Ace Therapeutics provides world-class in vitro ADME services for global customers' ophthalmic small molecule product development. You will benefit from our state-of-the-art facilities, extensive expertise and decades of drug development experience. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

• In Vitro Safety and Pharmacology Services
• Early Ocular Toxicology Services
• Ocular Pharmacokinetic (PK) Services
• Ocular Pharmacology and Pharmacodynamics Services

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• * All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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