What is Ocular Toxicity?

Preclinical toxicology and associated safety studies are critical parts of the drug development life cycle. They are needed to demonstrate that test compounds are safe, and at what doses, to be administered to humans as part of clinical trials. Start your safety and toxicology program with a powerful strategy to anticipate problems and avoid costly delays. Ocular toxicity assessment is an integral process in the development of compounds targeting ocular diseases. Ocular toxicity is characterized by one or more adverse changes affecting the structure or function of the eye following application of a substance, drug, or device directly to or in the eye or other parts of the body away from the eye. In the most severe cases, ocular toxicity may result in eye pain and/or irreversible vision loss.

Services Overview

Non-clinical eye models can be in vitro systems or specially bred animals. They provide research scientists with detailed information about the efficacy and/or safety of substances, drugs, or devices developed to address specific human eye diseases. Ace Therapeutics develops a variety of ocular disease models for ocular toxicology studies to evaluate these models and the therapies they are developing.

Our talented team of ophthalmology specialist team conduct safety and efficacy studies using intravitreal injections, topical instillations, subretinal administration, and other routes of systemic exposure. As a comprehensive preclinical CRO in ophthalmology, our ocular toxicology services target therapeutics for a range of diseases and conditions. These include age-related macular degeneration, diabetic retinopathy, glaucoma and more.

How Can We Support Ocular Product Development?

Thanks to our most experienced ocular pathology team, our knowledge and expertise in performing specialist pathology assessments of ocular tissue will support clients with any ocular toxicology study needs. Such support includes routine paraffin or frozen sectioning, immunohistochemistry, and electron microscopy.

Our Routes of Administration

• Intravitreal
• Intracameral
• Subconjunctival/tenons
• Subretinal
• Topical
• Systemic

Our Technology and Methods

• Electroretinogram (ISCEV)
• Spectral-domain optical coherence tomography (SD-OCT) and retinal layer segmentation
• Pachymeter (corneal thickness)
• Digital focus photography/video
• Confocal scanning laser ophthalmoscopy (CSLO).
• Fundus autofluorescence
• Fluorescein angiography (FA)
• Indocyanine green angiography (ICG).
• Vitrectomy
• Aqueous/vitreous humor collection and biomarker quantification
• Slit lamp for biomicroscopy
• Indirect and direct ophthalmoscopy
• Gonioscopy
• Streak retinoscopy
• Eye reflex

What Species do We Work With?

We have expertise and access to a range of preclinical models. Our species include:

• Mouse
• Rat
• Guinea Pig
• Rabbit
• Puppy
• Monkey
• Pigs, miniature pigs
• Sheep
• Goat

Tanks to our rich experience and leading technology platform, Ace Therapeutics provides professional Early Ocular Toxicology Studies services to help global customers identify and select the best compounds for their ophthalmic small molecule drug discovery programs. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

• In Vitro Safety and Pharmacology Services
• In Vitro ADME Services
• Ocular Pharmacokinetic (PK) Services
• Ocular Pharmacology and Pharmacodynamics Services

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