Customized Rabbit Models of Normotensive & Hypertensive Intraocular Pressure

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Ocular hypertension is a major risk factor for glaucoma. Elevated intraocular pressure (IOP) is the only known modifiable risk factor for glaucoma and all existing interventions work by reducing IOP. To help global customers test the efficacy of IOP-lowering therapeutics, Ace Therapeutics offers the intravitreal hypertonic saline rabbit model of normotensive & hypertensive intraocular pressure (IOP). With extensive experience in preclinical development, our dedicated research team will help you investigate your drug, thus advancing your project quickly to the next stage.

Rabbit Models of Normotensive & Hypertensive Intraocular Pressure

Normotensive & Hypertensive Intraocular Pressure (IOP)

Glaucoma is a devastating disease that causes damage to the optic nerve and loss of visual function. It is the leading cause of blindness in adults. Intraocular pressure (IOP) is the main parameter for evaluating glaucoma patients, and its maintenance depends on the dynamic balance between aqueous humor formation and outflow. An important indicator in glaucoma research, it provides baseline stress in eye disease research. Crucially, although the pathogenesis of glaucoma is not fully understood, it is believed that increased IOP is a major contributor even in normal tension glaucoma Therefore, it is necessary to develop suitable animal models to effectively simulate the etiology and pathological process of glaucoma and to study the effect of elevated IOP on the degeneration of the optic nerve and RGC.

Fig. 1. Schematic diagram of the circulation of aqueous humor. (Xia Q, et al., 2022)

Service Overview

Glaucoma is typically characterized by elevated intraocular pressure, and lowering intraocular pressure is the most commonly used glaucoma treatment method. Leveraging extensive experience in the field of ocular disease models, Ace Therapeutics is committed to providing a set of normotensive and hypertensive intraocular pressure New Zealand white rabbit models that have been shown to examine the onset and pathological progression in a controlled, reproducible manner. To verify the model's reliability, our talented scientists conduct a full range of tests, including but not limited to:

Intraocular pressure measurement.
Fundus photography (color).
Ocular coherence tomography (OCT).
Optomotry.
Pathological analyses and imaging.

Explore Ace Therapeutics' Rabbit Models of Normotensive & Hypertensive Intraocular Pressure

The Ace Therapeutics rabbit model of ocular hypertension was created by injecting 5% hypertonic saline into the vitreous of New Zealand white rabbits. This model characterizes efficacy in systems with elevated IOP and can be used to evaluate IOP-lowering therapeutics.

Model characteristics: After New Zealand white rabbits were treated with 5% hypertonic saline, the IOP increased by about 100-150% within 30 minutes. The effect was rapid and significant, and this characteristic returned to normal naturally within 3 hours.

Importantly, our investigators also test whether the New Zealand white rabbit IOP model responded to these drugs using relevant clinical compounds. The results show that topical ocular treatments significantly reduced intraocular pressure in IOP New Zealand white rabbits.

Ace Therapeutics aims to provide global customers with a simple, low-cost and reproducible powerful tool for preclinical glaucoma research. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Ishikawa M, Yoshitomi T, Zorumski CF, et al. Experimentally Induced Mammalian Models of Glaucoma. Biomed Res Int. 2015, 2015:281214.
Xia Q, Zhang D, Zhuang Y, et al. Animal Model Contributions to Primary Congenital Glaucoma. J Ophthalmol. 2022, 2022:6955461.

For Research Use Only.

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