Why Chickens Can Study Human Retinal Diseases?

Clinically relevant causes of vision loss are retinal diseases, such as retinal detachment (RD), diabetic retinopathy (DR), retinal neurodegeneration, etc. They are common and can damage vision and the eye itself. Animal models, including intravitreal injections of chemicals, cells, and enzymes, are useful for studying vision loss caused by retinal damage. A powerful animal model for vision research, the chick has been used to model retinal diseases in humans. Advantages include genome sequencing, large eyes, relative ease of handling and maintenance, and ready availability.

Fig. 1. Retina cross section of different vertebrate retinas compared to the chicken retina. (Seifert M, et al., 2020)

Service Overview

As a research expert in ocular diseases, Ace Therapeutics is happy to provide you with high-quality, high-standard chicken models of retinal damage to advance your projects.

Importantly, in order to assess the pathology of retinal damage in chicks and to test novel therapies, Ace Therapeutics also offers the following analytical tools, including but not limited to:

• Histopathological analysis.
• Western blot analysis.
• Immunohistochemical analysis.
• Bioinformatics analysis.

Explore Ace Therapeutics' Chicken Models of Retinal Injury

Ace Therapeutics has developed several chick models for studying retinal damage, including:

• Chicken models of rhegmatogenous retinal detachment

Ace Therapeutics' researchers induce a chick retinal injury model by subretinal injection of hyaluronic acid to isolate the retina. The follow-up period was 21 days. This model is a cone-rich research model that can help you conduct high-throughput research on neuroprotective or antiproliferative agents that improve RD.

• Chicken models of diabetic retinopathy

Ace Therapeutics' researchers induce chicken models of diabetic retinopathy by injecting a glucose solution containing a certain dose of STZ into fertilized chicken eggs. This model, developed in embryonic chickens, is a cone-rich diabetic retina model that can be used primarily to study macular thinning observed in offspring of mothers with gestational diabetes.

• Chicken model of NMDA-induced retinal injury

Ace Therapeutics' NMDA-induced retinal injury model was created by intravitreal injection of N-methyl-D-aspartic acid (NMDA) into chicks. NMDA is an excitatory neurotransmitter of the central nervous system that causes retinal excitotoxic injury, with neuronal apoptosis concentrated in the inner retinal layer. You can choose this model to study the mechanisms involved in retinal degeneration and to test the effects of potential neuroprotective therapies.

It is worth mentioning that our chicken retinal injury model is not limited to these types. Our ophthalmic pharmacologists are always on top of the development of updated models, and our expert team can develop customized retinal injury models according to your needs.

Ace Therapeutics aims to provide a powerful analytical tool to help our global customers explore the physiological and pathological mechanisms of human retinal diseases. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Seifert M, Baden T, Osorio D. The retinal basis of vision in chicken. Semin Cell Dev Biol. 2020, 106:106-115.
2. Cebulla CM, Zelinka CP, Scott MA, et al. A chick model of retinal detachment: cone rich and novel. PLoS One. 2012, 7(9):e44257.
3. Shi L, Ko ML, Huang CC, et al. Chicken embryos as a potential new model for early onset type I diabetes. J Diabetes Res. 2014, 2014:354094.
4. Fischer AJ, Scott MA, Zelinka C, et al. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Müller glia. Glia. 2010,58(6):633-49.

• Customized Chicken Models of Myopia
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• Customized Chicken Models of Corneal Wound Healing

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