Advantages of Chicken Inherited Ocular Disease Models

Over the past few decades, researchers have identified multiple chicken lines with highly penetrant, spontaneously occurring mutations in the ocular phenotype. These mutant strains offer a possible opportunity to study human monogenic diseases including ocular albinism, retinal dystrophies (such as Leber congenital amaurosis), and defects, as well as the common complex traits of glaucoma and myopia. In addition, the chick has been the model organism of choice for studies of embryonic development. This allows for the study of eye development in health and disease by creating novel mutants through gene editing, knock-in, and knock-out combined with primordial germ cell culture. This is mainly due to 1) Embryos being easily cultured in open eggshells, allowing manipulation of cells and tissues in culture or in ovo. 2) Embryos can be manipulated to study eye development and cells can be transfected with transgenes by electroporation and organization. 3) Genes can be added to the germline via lentiviral vectors to study gene function in vivo. 4) Transgenic chickens can be used to track the development of specific cells or tissues.

Fig. 1. The albino chick eye contains no melanin. (Rymer J, et al., 2007)

Service Overview

As one of the global leaders in eye disease models, Ace Therapeutics not only provides customers with traditional eye disease models, but we are pleased to also provide a series of genetic eye disease chicken models.

At Ace Therapeutics, we have a team of excellent chicken genetic eye disease research experts who are committed to exploring pathogenic mechanisms related to human biology and genetics. For example, our albino chicken mutants share some ocular characteristics with human albino chickens, including red eyes (due to lack of pigment and showing underlying choroidal vessels), decreased vision, and increased refractive abnormalities. This is an excellent model for studying ocular pathology caused by albinism. Chickens with retinal degeneration exhibit loss of retinal guanylate cyclase-1 (RetGC1) activity and serve as a model for Leber congenital amaurosis type 1 (LCA1).

Overall, the advantage of these genetic models is that they can help you obtain the results of a series of biological studies at the gene, cell, and tissue levels. These are critical tools for interpreting pathological information about human eye diseases.

Explore Ace Therapeutics' Chicken Models of Inherited Eye Disease

Ace Therapeutics provides the following chicken models of inherited eye diseases to customers worldwide, including but not limited to:

Tab.1. Ace Therapeutics' chicken models of inherited eye disease.

Importantly, our ophthalmic pharmacologist develop standardized experimental protocols to test the response of potential therapies to these chicken inherited eye diseases.

Ace Therapeutics aims to provide powerful analytical tools to help our global customers explore the biological mechanisms of human inherited eye diseases. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Wisely CE, Sayed JA, Tamez H, et al. The chick eye in vision research: An excellent model for the study of ocular disease. Prog Retin Eye Res. 2017, 61:72-97.
2. Rymer J, Choh V, Bharadwaj S, et al. The albino chick as a model for studying ocular developmental anomalies, including refractive errors, associated with albinism. Exp Eye Res. 2007, 85(4):431-42.

• Customized Chicken Models of Myopia
• Customized Chicken Models of Hyperopia
• Customized Chicken Models of Retinal Injury
• Customized Chick Embryo Models of Uveal Melanoma
• Customized Chicken Models of Corneal Wound Healing

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