Advantages of Chicken Embryos for Uveal Melanoma

Uveal melanoma (UM) is one of the most common primary intraocular malignancies in adults. Compared with other tumor entities, the treatment of uveal melanoma and its metastases is still underdeveloped. Despite improvements in traditional treatment regimens and new discoveries about the genetic and molecular background of primary tumors, effective therapeutic strategies to prevent tumors or treat patients with advanced or metastatic disease are still lacking. To achieve satisfactory local tumor control, reduce the risk of metastatic development, and preserve the eyeball and possibly the visual function of the eye, new treatment options are needed. The development of in vivo model systems remains critical for the identification and study of potential novel therapeutic modes. Chicken embryos have been reported in various cancer types as a model for studying tumor metastasis. In the chicken embryo model, the tissue composition and accessibility of the chick chorioallantoic membrane (CAM) for experimental interventions have enabled the visualization and tracking of the fate of transplanted tumor cells, advancing cancer research. The model is cost-effective and supports many alternatives to animal experiments.

Fig. 1. Homing of GFP-labelled uveal melanoma cells to the chick embryo eye. (Kalirai H, et al., 2015)

Service Overview

The chicken embryo is a common model used to study UM at Ace Therapeutics. In recent years, Ace Therapeutics researchers have successfully developed a variety of UM models through continuous experimental exploration. We are pleased to offer you a chicken embryo model of uveal melanoma to evaluate the orthotopic growth of uveal melanoma cells in corn. Importantly, our researchers also develop a chorioallantoic membrane (CAM) assay to assess the ability of uveal melanoma cells to form tumor masses on the CAM and spread to internal organs through the chicken circulation.

To assess tumor cell growth in chicken embryos, Ace Therapeutics monitors with the following analytical tools, including but not limited to:

• Optical coherence tomography and infrared imaging.
• Optical coherence tomography and angiography.
• Fundus fluorescein angiography.
• Histology and immunohistochemistry.

Explore Ace Therapeutics' Chick Embryo Models of Uveal Melanoma

Ace Therapeutics' chicken embryonic uveal melanoma model was created by injecting cultured human uveal melanoma cells into the eyes of embryonic chickens at a stage when the immune system is immature. This embryonic model shows no abnormal eye development with a high survival rate.

Application Fields

• Studying the growth and possible metastatic behavior of human uveal melanoma cells.
• Testing some compounds that may treat UM.

Ace Therapeutics aims to provide global customers with a powerful experimental tool to evaluate the effectiveness of potential therapies against uveal melanoma. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Kalirai H, Shahidipour H, Coupland SE, et al. Use of the Chick Embryo Model in Uveal Melanoma. Ocul Oncol Pathol. 2015, 1(3):133-40.
2. Wisely CE, Sayed JA, Tamez H, et al. The chick eye in vision research: An excellent model for the study of ocular disease. Prog Retin Eye Res. 2017, 61:72-97.

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