What is Computer-Aided Target Identification and Validation?

The first critical stage of small-molecule drug research is the identification and validation of drug targets. Traditional drug-target prediction is mostly based on systems biology, including genome-wide association scans, gene expression analysis from tissues to single cells, miRNA analysis, proteomics, metabolomics, post-translational modifications, cell imaging, etc. This method is time-consuming and expensive. For faster and more accurate identification of possible drug targets, various computer-aided means have been developed, including sequence-driven methods and structure-based methods, which provide valuable strategies for systematic prediction of potential drug targets due to their high efficiency and low cost. Computer-aided target identification and verification is a virtual operation that uses computational methods to find and verify putative targets in various databases. This is a highly collaborative approach that relies on systems biology tools and associated computations.

Services Overview

Identifying and verifying new drug targets is the first critical step in curing diseases. It not only provides significant information for revealing the mechanism of drug action, but also has significant significance for the development of new drugs, the establishment of screening models, and the discovery of lead compounds. With the rapid development of artificial intelligence and machine learning technology, computer-aided target identification and verification has become a crucial way to discover drug targets. It is widely used by our customers because of its high precision and high efficiency. At Ace Therapeutics, our team of experts helps clients extract knowledge from numerous sources to make science-based decisions about drug target identification.

Ace Therapeutics' Computer-Aided Target Identification and Validation Services

As an industry leader in the field of ophthalmology, Ace Therapeutics provides professional computer-aided target identification and validation services to support the discovery of ophthalmic small molecule lead compounds. Ace Therapeutics has an interdisciplinary professional computer team and sophisticated software for bioinformatics, cheminformatics, molecular biology, genetics, and positional informatics. Using these software, the mechanism of action between the drug and the target can be revealed and the target can be explored.

What appeals to our clients is that our expert team incorporates genetic evidence of a target-eye disease association into the experimental design, as genetically proven disease-associated targets are more likely to be successful in delivering active substances. In addition, our computer scientists use the drug target information in the bioinformatics database to systematically prioritize drug targets. This reduces the probability of error, enabling you to fully invest in research. Our services include but are not limited to.

• In-Silico Target Forecast

In silico predictions provide a powerful tool for discovering therapeutic drug targets for single molecules of interest. Ace Therapeutics utilizes virtual screening methods, including 2D similarity search, 3D pharmacophore search, and high-throughput docking, for screening databases in protein and compound libraries to predict potential targets.

• In-Silico Protein Modeling

Accurate structures can provide reliable results for structure-based drug design, functional analysis, and toxicity prediction. Based on a variety of computer software platforms, Ace Therapeutics provides computer protein modeling services to global customers to predict the secondary and tertiary structures of target proteins. Our approach includes homology modeling, protein threading (or fold identification), and ab initio methods.

• Computer Function Analysis

Functional analysis customized by our professional team combines multiple data sources covering metabolic pathways, biomarkers, small molecule modulators, target compound interactions, etc. To provide holistic information for any specific target. Our world-class in-silico analysis enables researchers to determine the genetic basis and characterize the functional potential of ocular disorders.

Our Advantages

• Autonomous route design for complex target molecules and timely implementation.
• Eye disease association research.
• Data mining using bioinformatics.
• Extensive experience in computer-aided target identification and validation.
• Powerful in silico tools for target identification and verification.

Thanks to a powerful computer-aided platform, Ace Therapeutics provides various bioinformatics information, such as gene expression, proteomics and transgenic phenotype analysis to support the target identification and validation phase of customers' ophthalmic small molecule lead compounds. Our computer-aided platform offers high accuracy and short turnaround times. If you are interested in our services or need more details, please feel free to contact us or send us an inquiry directly.

• RNAi-Based Target Screening
• Gene Expression Profiling-Based Screening
• Genetic Engineering-Based Target Screening
• CRISPR/Cas9-Based Target Screening
• Label-Free Target ID
• Mechanism of Action (MOA) Study
• Target Functional Annotation and ID
• Target Structure Determination

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