Preclinical R&D Services for Ulcerative Colitis

Ace Therapeutics has extensive experience in the study of various gastrointestinal diseases. We can provide customized preclinical services to support clients' ulcerative colitis research, including the development and validation of disease models, and the development of novel drugs for the therapy of ulcerative colitis.

Introduction to Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disease of the colonic mucosa with unknown etiology. Clinical symptoms of ulcerative colitis are typically characterized by persistent or recurrent abdominal pain, diarrhea, and mucopurulent bloody stools. The condition may be confined to the rectum or extend proximally, occasionally affecting the entire colon.

Today, there are significant advances in drug research for multiple ulcerative colitis, with a wide range of therapeutic approaches, from optimization of traditional treatments to the development of novel targeted drugs and biologic therapies.

Fig. 1 The immunological composition and function of the appendix in health and ulcerative colitis. (Agrawal M, et al., 2023)

What Can We Do?

Leveraging our expertise in gastrointestinal disease research, our team of scientists can design a customized ulcerative colitis research plan customized to meet our clients' specific experimental needs.

Ulcerative Colitis Model Development Services

Animal models are important tools for ulcerative colitis research. Based on our professional animal model construction technology platform, we provide customized experimental animal models of ulcerative colitis according to clients' research needs.

• Chemical-induced Ulcerative Colitis Models
  DSS-induced Uncreative Colitis Models
  TNBS-induced Uncreative Colitis Models
  OXA-induced Uncreative Colitis Models
  Acetic acid-induced Uncreative Colitis Models
• Transgene/Knockout Ulcerative Colitis Models
  TCR α ^-/- Mouse Model
  WASP ^-/- Mouse Model
  Mdr1a ^-/- Mouse Model
  IL-2 ^-/- Mouse Model
  IL-10 ^-/- Mouse Model

Basic Research Services for Ulcerative Colitis

We offer a variety of basic research services related to ulcerative colitis, including the identification and characterization of ulcerative colitis-specific biomarkers, and the study of the underlying pathogenesis of ulcerative colitis from the perspective of multi-omics or the regulation of intestinal flora.

Drug Development Services for Ulcerative Colitis

Since the etiology and pathogenesis of ulcerative colitis have not been fully elucidated, the current drug therapy strategy for ulcerative colitis is mainly to relieve inflammation and symptoms. We can provide the following services for drug development of ulcerative colitis.

• We help develop small molecule inhibitors that target inflammatory signaling pathways to inhibit inflammatory responses in the colon.
• We can develop biologics such as antibodies against inflammatory cytokines or immune cells to target and inhibit the onset of the colonic inflammatory response.
• Gut microbiota is also one of the emerging approaches to address the therapy of ulcerative colitis. We can help our clients develop probiotics or microbial agents to modulate the gut microbiota and gut inflammation.

Ace Therapeutics has a scientist team that provides specialized research services in the field of gastroenterology. We can offer customized research plan for clients according to experimental needs. If you would like to learn more about our services, please do not hesitate to contact us.

Reference

1. Agrawal, M.; Allin, K.H.; Mehandru, S.; et al. The appendix and ulcerative colitis - an unsolved connection. Nat Rev Gastroenterol Hepatol. 2023, 20(9):615-624.

Our products and services are for research use only and can not be used for diagnostic or other purposes.