As the global burden of gastrointestinal (GI) and liver diseases continues to rise, the need for robust preclinical research to drive therapeutic innovation has never been more crucial. At Ace Therapeutics, we are dedicated to empowering our clients with a comprehensive suite of specialized contract research services to accelerate research, enhance understanding, and develop effective interventions for gastrointestinal and hepatic disorders.
Our Preclinical Gastroenterology & Hepatology CRO Services
- Preclinical Gastroenterology CRO Services
GRED, Gastric ulcer, gastritis, appendicitis, Crohn disease, IBD, IBS
- Preclinical Hepatology CRO Services
NALDs, ALDs, hepatitis, fatty liver, liver fibrosis, liver failure, pancreatitis, pancreatic microcirculation disorder, cholecystitis, cholangitis, biliary atresia, gallstone
Our Capabilities of Basic Research in Gastroenterology & Hepatology
Investigating esophageal motility disorders
High-resolution manometry (HRM), impedance testing, ex vivo tissue studies, and contractility assays.
Studying gastric mucosal protection mechanisms
Gastric acid secretion assays, mucosal barrier integrity testing, and in vitro gastric cell culture models.
Understanding nutrient absorption pathways
Intestinal permeability assays, brush border enzyme activity assays, and epithelial cell culture studies.
Investigating gut microbiota interactions
16S rRNA sequencing, fecal microbiota transplantation (FMT), colonic inflammation models, and microbial metabolite analysis.
Exploring hepatic stellate cell activation in fibrosis
Liver fibrosis models (e.g., bile duct ligation), hepatic cell isolation, gene expression profiling, and fibrosis biomarker analysis.
Investigating pancreatic enzyme regulation
Pancreatic enzyme activity assays, pancreatic acinar cell isolation, exocrine secretion studies, and pancreatic duct physiology assessments.
Our One-Stop Drug Development Services in Gastroenterology & Hepatology
- Disease Mechanism Exploration & Target Identification
At Ace Therapeutics, our specialized in vitro and in vivo models allow customers to profile disease signatures, elucidate altered molecular networks, and understand cellular phenotypes through functional genomics. Our expertise extends to discovering and validating novel pathways and proteins involved in disease initiation and progression.
- Drug Candidate Screening & Discovery
By leveraging high-throughput screens of extensive compound libraries and employing in silico modeling, we can rapidly identify lead candidates with targeted properties. Through secondary assays, we confirm target engagement and mechanism of action, ensuring the selection of promising hits for further development.
- In Vitro and In Vivo Pharmacodynamic Studies
Leveraging the latest advancements in stem cell technology, organoid engineering, and genome editing, we create customized in vitro and in vivo models tailored to the unique needs of each customers' program. Our team can perform thorough target inhibition and pathway modulation analyses to evaluate the pharmacodynamic effects of drug candidates.
- Pharmacokinetic & Biodistribution Studies
Our advanced bioanalytical technologies allow us to help customers quantify compounds and metabolites in plasma and tissue matrices, providing data on absorption, distribution, metabolism and excretion parameters over time. Using our imaging technologies, such as PET/CT and SPEC/CT, as well as mass spectrometry imaging technology, you can also obtain information about the distribution of drugs in the body.
Ace Therapeutics specializes in the assessment of general toxicity, liver/gut injury, and drug-induced organ damage through histopathology and serum biomarker analysis. Through targeted studies of mitochondrial dysfunction, apoptosis, and genotoxicity, we help you fully understand the mechanisms of toxicity and optimize the safety of your compounds.
Highlights of Our Preclinical Gastroenterology & Hepatology CRO Services
- Organ-Specific Research: Focuses on specific organs within gastroenterology and hepatology, including the esophagus, stomach, small intestine, large intestine (colon), liver, gallbladder, bile ducts, and pancreas.
- Specialized Expertise: Conducts fundamental research on physiological processes, cell signaling pathways, tissue responses, and organ function using a variety of techniques and models.
- Comprehensive Services: Performs preclinical evaluations of potential therapeutics, including efficacy assessments, safety profiles, pharmacokinetics, and pharmacodynamics studies.
From advanced cell culture systems and high-throughput screening platforms to specialized in vivo imaging modalities and multi-omics analytical pipelines, Ace Therapeutics invests heavily in the latest technologies to ensure the highest level of data integrity and reproducibility. By leveraging our expertise and resources, researchers and pharmaceutical companies can pursue innovative solutions to address the challenges posed by gastrointestinal and hepatic diseases. Please feel free to Contact us and discuss your specific needs.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
