Integrated R&D Services

Drug R&D Services
- By Target
  - COX-2
  - H2 Receptor
  - Proton Pump
  - ClC-2
  - Guanylate Cyclase-C
  - NHEs
  - JAKs
  - Phosphodiesterases
- By Research Phase
IVD R&D Services
Vaccine R&D Services
Preclinical Gastroenterology & Hepatology CRO Services
- Preclinical Gastroenterology CRO Services
- Preclinical Hepatology CRO Services

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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Preclinical Gastroenterology CRO Services

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At Ace Therapeutics, we understand the unique challenges associated with developing novel candidate drugs for gastrointestinal diseases. We offer customized preclinical services to support your research and development needs, including the development and validation of disease models, in vitro pharmacodynamic platforms, and in vivo efficacy and safety studies. Our specialized expertise also includes conducting biomarker detection, pharmacokinetic evaluations, toxicology assessments and analytical method development.

What Gastrointestinal Diseases Do We Offer Preclinical Research Services for?

Gastroesophageal reflux disease (GERD)
Gastric ulcers and duodenal ulcers
Irritable bowel syndrome (IBS)
Gastrointestinal cancers
Celiac disease
Gastrointestinal infections
Clostridium difficile infection
Gastrointestinal dysmotility disease
Crohn disease

What Can We Do for Preclinical Gastroenterology Research?

Gastrointestinal Disease Pathology Research Preclinical Pharmacodynamic Services Pharmacokinetic and Toxicology Studies Biomarker Analysis

Conduct detailed investigations and analyses of various gastrointestinal diseases to understand their pathology, underlying mechanisms, and potential therapeutic targets.
Utilize advanced techniques to study tissue samples, cellular models, and animal models to gain insights into disease progression, molecular pathways, and biomarker identification.

Design and execute preclinical studies to evaluate the efficacy and safety of potential drug candidates for gastrointestinal diseases.
Develop and utilize disease models that mimic pathological conditions to assess the therapeutic potential of novel interventions.
Conduct in vitro studies using cell-based assays and organoid cultures to evaluate drug efficacy, mechanism of action, and toxicity profiles.
Perform in vivo studies using animal models to assess the pharmacokinetics, pharmacodynamics, and therapeutic responses of drug candidates.
Provide comprehensive data analysis, interpretation, and reporting to support informed decision-making in drug development.

Conduct pharmacokinetic studies to evaluate drug absorption, distribution, metabolism, and excretion (ADME) properties.
Assess the safety and potential toxicities of drug candidates through comprehensive toxicology studies, including acute, subchronic, and chronic toxicity evaluations.
Perform in vitro and in vivo drug-drug interaction studies to assess potential interactions and optimize therapeutic regimens.

Identify and validate biomarkers associated with gastrointestinal diseases to aid in disease diagnosis, prognosis, and treatment monitoring.
Utilize advanced molecular techniques, such as genomics, proteomics, and metabolomics, to identify and analyze disease-specific biomarkers.

Our One-Stop Drug Development Services

We offer best-in-class biophysical technologies such as ASMS, Intact-MS, Native-MS, HDX-MS, TSA, SPR, supporting biologic drug discovery from target ID and validation to screening and structure-based design.

Recombinant protein expression and purification
Protein structure analysis
Antigen-antibody structure analysis
Drug screening
Biomolecular interaction analysis
Antibody discovery and affinity maturation services

Biologic Development Services

Combining medicinal chemistry, synthesis, analytics and computational capabilities, we provide integrated small molecule discovery solutions from virtual screening to purification.

Computer-aided drug design
Pharmaceutical chemistry
Synthesis chemistry
Analytical chemistry
Purification and preparation

Chemical Drug Development
Services

Leveraging our protein production and structural expertise, we enable all aspects of PROTAC/molecular glue R&D from protein co-crystallization to screening, kinetics analysis, metabolism profiling, and compound optimization.

Protein preparation and ternary system structure research
PROTAC design and synthesis
PROTAC/molecular glue screening
PROTAC activity detection
PROTAC ternary system dynamics study
PROTAC molecular drug metabolism research

PROTAC & Molecular Glue
Development Services

Through our proprietary XDC platform integrating antibody, peptide and small molecule conjugation know-how, we offer comprehensive integrated conjugated drug development from design to functional assessment.

XDC design
Isotopic labeling
XDC efficacy study
RDC biodistribution study

XDC Development Services

Ace Therapeutics is a leading provider of specialized preclinical contract research services to support the development of novel therapeutics in gastroenterology. Our expert team specializes in conducting a comprehensive range of studies related to gastrointestinal diseases such as inflammation, motility disorders, cancer and more. We offer customized solutions for all stages of drug discovery and development. Contact us today to discuss your unique research needs and timelines.

Our products and services are for research use only and can not be used for diagnostic or other purposes.